Plasma total-tau as a biomarker of stroke risk in the community

Matthew P. Pase, Jayandra J. Himali, Hugo J. Aparicio, Jose Rafael Romero, Claudia L. Satizabal, Pauline Maillard, Charles DeCarli, Alexa S. Beiser, Sudha Seshadri

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)


Higher plasma total-tau level is associated with incident dementia, but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2,794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom 4, had an increased risk of incident stroke over a mean follow-up of 8.3 years (hazard ratio = 2.01; 95% confidence interval = 1.32–3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. ANN NEUROL 2019;86:463–467.

Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalAnnals of Neurology
Issue number3
Publication statusPublished - Sept 2019
Externally publishedYes

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