Projects per year
Abstract
Scope: Iron plays an important role in the pathogenesis of insulin resistance (IR) and type 2 diabetes. Recent studies suggest a role of specific lipids in the induction of IR, but the potential relationships between iron and lipid metabolites in relation to IR have not been explored. Therefore, the aim of the study is to evaluate the association among iron, IR, and the lipidome. Methods and results: The plasma lipidome, IR, parameters of iron metabolism, and several cytokines and adipokines in 65 overweight/obese participants are measured. Measurements of IR correlate positively with ferritin, a measure of iron storage (r = 0.35, p = 0.005), and negatively with adiponectin (r = −0.30, p = 0.02). The serum ferritin/adiponectin ratio has a stronger association with IR (r = 0.41, p < 0.001). From multivariate analyses adjusted for age, sex, and BMI, several phospholipids containing long chain polyunsaturated fatty acids (PUFA) with 20–22 carbons (phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, and a phosphatidylserine), are positively associated with ferritin and the ferritin/adiponectin ratio. Two dihydroceramides (Cer(18:0/22:0), Cer(18:0/24:0)) and several diglycerides and triglycerides, mainly comprised of C14:0, C16:0, C18:0, C18:1, and C18:2, also have positive correlations with ferritin and the ferritin/adiponectin ratio. Conclusions: The positive associations between these lipid species and ferritin or the ferritin/adiponectin ratio suggest a potential crosstalk between iron and lipid metabolism in obesity and IR.
Original language | English |
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Article number | 1901055 |
Number of pages | 11 |
Journal | Molecular Nutrition & Food Research |
Volume | 64 |
Issue number | 5 |
DOIs | |
Publication status | Published - Mar 2020 |
Keywords
- diabetes
- ferritin
- insulin resistance
- iron
- lipidomics
Projects
- 2 Finished
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Novel approaches to prevent type 2 diabetes and cardiovascular disease by reducing chronic low grade inflammation and advanced glycation.
de Courten, B.
National Heart Foundation of Australia
1/01/16 → 31/12/19
Project: Research
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Can vitamin D prevent diabetes by improving insulin sensitivity and secretion in overweight humans?
de Courten, B., De Courten, M., Scragg, R. & Walker, K.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 31/12/17
Project: Research