Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families

Hemant Kulkarni, Peter J. Meikle, Manju Mamtani, Jacquelyn M Weir, Marcio A Alfonso de Almeida, Vincent Diego, Juan Manuel Peralta, Christopher K. Barlow, Claire Bellis, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Anthony G Comuzzie, Harald H H Göring, Joanne E Curran, John Blangero

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Plasma lipidome is now increasingly recognized as a potentially important marker of chronic diseases, but the exact extent of its contribution to the interindividual phenotypic variability in family studies is unknown. Here, we used the rich data from the ongoing San Antonio Family Heart Study (SAFHS) and developed a novel statistical approach to quantify the independent and additive value of the plasma lipidome in explaining metabolic syndrome (MS) variability in Mexican American families recruited in the SAFHS. Our analytical approach included two preprocessing steps: principal components analysis of the highresolution plasma lipidomics data and construction of a subject-subject lipidomic similarity matrix. We then used the Sequential Oligogenic Linkage Analysis Routines software to model the complex family relationships, lipidomic similarities, and other important covariates in a variance components framework. Our results suggested that even after accounting for the shared genetic influences, indicators of lipemic status (total serum cholesterol, TGs, and HDL cholesterol), and obesity, the plasma lipidome independently explained 22% of variability in the homeostatic model of assessment-insulin resistance trait and 16% to 22% variability in glucose, insulin, and waist circumference. Our results demonstrate that plasma lipidomic studies can additively contribute to an understanding of the interindividual variability in MS. - Kulkarni, H., P. J. Meikle, M. Mamtani, J. M. Weir, M. Almeida, V. Diego, J. M. Peralta, C. K. Barlow, C. Bellis, T. D. Dyer, L. Almasy, M. C. Mahaney, A. G. Comuzzie, H. H. H. Göring, J. E. Curran, and J. Blangero. Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. J. Lipid Res . 2014. 55: 939-946.

Original languageEnglish
Pages (from-to)939-946
Number of pages8
JournalJournal of Lipid Research
Volume55
Issue number5
DOIs
Publication statusPublished - May 2014
Externally publishedYes

Keywords

  • Genetics
  • Insulin resistance
  • Lipidomics
  • Lipids
  • Obesity
  • Plasma lipidomics
  • Variance components

Cite this

Kulkarni, Hemant ; Meikle, Peter J. ; Mamtani, Manju ; Weir, Jacquelyn M ; de Almeida, Marcio A Alfonso ; Diego, Vincent ; Peralta, Juan Manuel ; Barlow, Christopher K. ; Bellis, Claire ; Dyer, Thomas D ; Almasy, Laura ; Mahaney, Michael C ; Comuzzie, Anthony G ; Göring, Harald H H ; Curran, Joanne E ; Blangero, John. / Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. In: Journal of Lipid Research. 2014 ; Vol. 55, No. 5. pp. 939-946.
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abstract = "Plasma lipidome is now increasingly recognized as a potentially important marker of chronic diseases, but the exact extent of its contribution to the interindividual phenotypic variability in family studies is unknown. Here, we used the rich data from the ongoing San Antonio Family Heart Study (SAFHS) and developed a novel statistical approach to quantify the independent and additive value of the plasma lipidome in explaining metabolic syndrome (MS) variability in Mexican American families recruited in the SAFHS. Our analytical approach included two preprocessing steps: principal components analysis of the highresolution plasma lipidomics data and construction of a subject-subject lipidomic similarity matrix. We then used the Sequential Oligogenic Linkage Analysis Routines software to model the complex family relationships, lipidomic similarities, and other important covariates in a variance components framework. Our results suggested that even after accounting for the shared genetic influences, indicators of lipemic status (total serum cholesterol, TGs, and HDL cholesterol), and obesity, the plasma lipidome independently explained 22{\%} of variability in the homeostatic model of assessment-insulin resistance trait and 16{\%} to 22{\%} variability in glucose, insulin, and waist circumference. Our results demonstrate that plasma lipidomic studies can additively contribute to an understanding of the interindividual variability in MS. - Kulkarni, H., P. J. Meikle, M. Mamtani, J. M. Weir, M. Almeida, V. Diego, J. M. Peralta, C. K. Barlow, C. Bellis, T. D. Dyer, L. Almasy, M. C. Mahaney, A. G. Comuzzie, H. H. H. G{\"o}ring, J. E. Curran, and J. Blangero. Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. J. Lipid Res . 2014. 55: 939-946.",
keywords = "Genetics, Insulin resistance, Lipidomics, Lipids, Obesity, Plasma lipidomics, Variance components",
author = "Hemant Kulkarni and Meikle, {Peter J.} and Manju Mamtani and Weir, {Jacquelyn M} and {de Almeida}, {Marcio A Alfonso} and Vincent Diego and Peralta, {Juan Manuel} and Barlow, {Christopher K.} and Claire Bellis and Dyer, {Thomas D} and Laura Almasy and Mahaney, {Michael C} and Comuzzie, {Anthony G} and G{\"o}ring, {Harald H H} and Curran, {Joanne E} and John Blangero",
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Kulkarni, H, Meikle, PJ, Mamtani, M, Weir, JM, de Almeida, MAA, Diego, V, Peralta, JM, Barlow, CK, Bellis, C, Dyer, TD, Almasy, L, Mahaney, MC, Comuzzie, AG, Göring, HHH, Curran, JE & Blangero, J 2014, 'Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families' Journal of Lipid Research, vol. 55, no. 5, pp. 939-946. https://doi.org/10.1194/jlr.M044065

Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. / Kulkarni, Hemant; Meikle, Peter J.; Mamtani, Manju; Weir, Jacquelyn M; de Almeida, Marcio A Alfonso; Diego, Vincent; Peralta, Juan Manuel; Barlow, Christopher K.; Bellis, Claire; Dyer, Thomas D; Almasy, Laura; Mahaney, Michael C; Comuzzie, Anthony G; Göring, Harald H H; Curran, Joanne E; Blangero, John.

In: Journal of Lipid Research, Vol. 55, No. 5, 05.2014, p. 939-946.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families

AU - Kulkarni, Hemant

AU - Meikle, Peter J.

AU - Mamtani, Manju

AU - Weir, Jacquelyn M

AU - de Almeida, Marcio A Alfonso

AU - Diego, Vincent

AU - Peralta, Juan Manuel

AU - Barlow, Christopher K.

AU - Bellis, Claire

AU - Dyer, Thomas D

AU - Almasy, Laura

AU - Mahaney, Michael C

AU - Comuzzie, Anthony G

AU - Göring, Harald H H

AU - Curran, Joanne E

AU - Blangero, John

PY - 2014/5

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N2 - Plasma lipidome is now increasingly recognized as a potentially important marker of chronic diseases, but the exact extent of its contribution to the interindividual phenotypic variability in family studies is unknown. Here, we used the rich data from the ongoing San Antonio Family Heart Study (SAFHS) and developed a novel statistical approach to quantify the independent and additive value of the plasma lipidome in explaining metabolic syndrome (MS) variability in Mexican American families recruited in the SAFHS. Our analytical approach included two preprocessing steps: principal components analysis of the highresolution plasma lipidomics data and construction of a subject-subject lipidomic similarity matrix. We then used the Sequential Oligogenic Linkage Analysis Routines software to model the complex family relationships, lipidomic similarities, and other important covariates in a variance components framework. Our results suggested that even after accounting for the shared genetic influences, indicators of lipemic status (total serum cholesterol, TGs, and HDL cholesterol), and obesity, the plasma lipidome independently explained 22% of variability in the homeostatic model of assessment-insulin resistance trait and 16% to 22% variability in glucose, insulin, and waist circumference. Our results demonstrate that plasma lipidomic studies can additively contribute to an understanding of the interindividual variability in MS. - Kulkarni, H., P. J. Meikle, M. Mamtani, J. M. Weir, M. Almeida, V. Diego, J. M. Peralta, C. K. Barlow, C. Bellis, T. D. Dyer, L. Almasy, M. C. Mahaney, A. G. Comuzzie, H. H. H. Göring, J. E. Curran, and J. Blangero. Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. J. Lipid Res . 2014. 55: 939-946.

AB - Plasma lipidome is now increasingly recognized as a potentially important marker of chronic diseases, but the exact extent of its contribution to the interindividual phenotypic variability in family studies is unknown. Here, we used the rich data from the ongoing San Antonio Family Heart Study (SAFHS) and developed a novel statistical approach to quantify the independent and additive value of the plasma lipidome in explaining metabolic syndrome (MS) variability in Mexican American families recruited in the SAFHS. Our analytical approach included two preprocessing steps: principal components analysis of the highresolution plasma lipidomics data and construction of a subject-subject lipidomic similarity matrix. We then used the Sequential Oligogenic Linkage Analysis Routines software to model the complex family relationships, lipidomic similarities, and other important covariates in a variance components framework. Our results suggested that even after accounting for the shared genetic influences, indicators of lipemic status (total serum cholesterol, TGs, and HDL cholesterol), and obesity, the plasma lipidome independently explained 22% of variability in the homeostatic model of assessment-insulin resistance trait and 16% to 22% variability in glucose, insulin, and waist circumference. Our results demonstrate that plasma lipidomic studies can additively contribute to an understanding of the interindividual variability in MS. - Kulkarni, H., P. J. Meikle, M. Mamtani, J. M. Weir, M. Almeida, V. Diego, J. M. Peralta, C. K. Barlow, C. Bellis, T. D. Dyer, L. Almasy, M. C. Mahaney, A. G. Comuzzie, H. H. H. Göring, J. E. Curran, and J. Blangero. Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families. J. Lipid Res . 2014. 55: 939-946.

KW - Genetics

KW - Insulin resistance

KW - Lipidomics

KW - Lipids

KW - Obesity

KW - Plasma lipidomics

KW - Variance components

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