Plasma levels of soluble CD14 independently predict mortality in HIV infection

Netanya Sandler, Handan Wand, Annelys Roque, Matthew G Law, Martha C Nason, Daniel E Nixon, Court Pedersen, Kiat Ruxrungtham, Sharon Ruth Lewin, Sean Emery, James D Neaton, Jason M Brenchley, Steven G Deeks, Irini Sereti, Daniel C Douek

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Abstract

This nested case-control study included 74 subjects who died, 120 of whom developed cardiovascular disease and 81 of whom developed AIDS during the Strategies for Management of Anti-Retroviral Therapy (SMART) study with matched control subjects. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody (EndoCAb), and 16S ribosomal DNA (rDNA) were measured in baseline plasma samples.
Original languageEnglish
Pages (from-to)780 - 790
Number of pages11
JournalJournal of Infectious Diseases
Volume203
Issue number6
DOIs
Publication statusPublished - 2011

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