Plasma levels of soluble CD14 independently predict mortality in HIV infection

Netanya Sandler; Handan Wand; Annelys Roque; Matthew G Law; Martha C Nason; Daniel E Nixon; Court Pedersen; Kiat Ruxrungtham; Sharon Ruth Lewin; Sean Emery; James D Neaton; Jason M Brenchley; Steven G Deeks; Irini Sereti; Daniel C Douek

doi:10.1093/infdis/jiq118

Plasma levels of soluble CD14 independently predict mortality in HIV infection

Netanya Sandler, Handan Wand, Annelys Roque, Matthew G Law, Martha C Nason, Daniel E Nixon, Court Pedersen, Kiat Ruxrungtham, Sharon Ruth Lewin, Sean Emery, James D Neaton, Jason M Brenchley, Steven G Deeks, Irini Sereti, Daniel C Douek

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

842 Citations (Scopus)

Abstract

This nested case-control study included 74 subjects who died, 120 of whom developed cardiovascular disease and 81 of whom developed AIDS during the Strategies for Management of Anti-Retroviral Therapy (SMART) study with matched control subjects. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody (EndoCAb), and 16S ribosomal DNA (rDNA) were measured in baseline plasma samples.

Original language	English
Pages (from-to)	780 - 790
Number of pages	11
Journal	The Journal of Infectious Diseases
Volume	203
Issue number	6
DOIs	https://doi.org/10.1093/infdis/jiq118
Publication status	Published - 2011

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Sandler, N., Wand, H., Roque, A., Law, M. G., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., Neaton, J. D., Brenchley, J. M., Deeks, S. G., Sereti, I., & Douek, D. C. (2011). Plasma levels of soluble CD14 independently predict mortality in HIV infection. The Journal of Infectious Diseases, 203(6), 780 - 790. https://doi.org/10.1093/infdis/jiq118

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title = "Plasma levels of soluble CD14 independently predict mortality in HIV infection",

abstract = "This nested case-control study included 74 subjects who died, 120 of whom developed cardiovascular disease and 81 of whom developed AIDS during the Strategies for Management of Anti-Retroviral Therapy (SMART) study with matched control subjects. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody (EndoCAb), and 16S ribosomal DNA (rDNA) were measured in baseline plasma samples.",

author = "Netanya Sandler and Handan Wand and Annelys Roque and Law, {Matthew G} and Nason, {Martha C} and Nixon, {Daniel E} and Court Pedersen and Kiat Ruxrungtham and Lewin, {Sharon Ruth} and Sean Emery and Neaton, {James D} and Brenchley, {Jason M} and Deeks, {Steven G} and Irini Sereti and Douek, {Daniel C}",

year = "2011",

doi = "10.1093/infdis/jiq118",

language = "English",

volume = "203",

pages = "780 -- 790",

journal = "The Journal of Infectious Diseases",

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TY - JOUR

T1 - Plasma levels of soluble CD14 independently predict mortality in HIV infection

AU - Sandler, Netanya

AU - Wand, Handan

AU - Roque, Annelys

AU - Law, Matthew G

AU - Nason, Martha C

AU - Nixon, Daniel E

AU - Pedersen, Court

AU - Ruxrungtham, Kiat

AU - Lewin, Sharon Ruth

AU - Emery, Sean

AU - Neaton, James D

AU - Brenchley, Jason M

AU - Deeks, Steven G

AU - Sereti, Irini

AU - Douek, Daniel C

PY - 2011

Y1 - 2011

N2 - This nested case-control study included 74 subjects who died, 120 of whom developed cardiovascular disease and 81 of whom developed AIDS during the Strategies for Management of Anti-Retroviral Therapy (SMART) study with matched control subjects. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody (EndoCAb), and 16S ribosomal DNA (rDNA) were measured in baseline plasma samples.

AB - This nested case-control study included 74 subjects who died, 120 of whom developed cardiovascular disease and 81 of whom developed AIDS during the Strategies for Management of Anti-Retroviral Therapy (SMART) study with matched control subjects. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody (EndoCAb), and 16S ribosomal DNA (rDNA) were measured in baseline plasma samples.

UR - http://www.natap.org/2011/HIV/JnfectDis90.pdf

U2 - 10.1093/infdis/jiq118

DO - 10.1093/infdis/jiq118

M3 - Article

VL - 203

SP - 780

EP - 790

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

SN - 0022-1899

IS - 6

ER -

Plasma levels of soluble CD14 independently predict mortality in HIV infection

Abstract

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