TY - JOUR
T1 - Plasma levels of oxidative stress in children with steroid-sensitive nephrotic syndrome and their predictive value for relapse frequency
AU - Fan, Aiwen
AU - Jiang, Xiaoyun
AU - Mo, Ying
AU - Tan, Huizhen
AU - Jiang, Mengjie
AU - Li, Jinhua
PY - 2016/1
Y1 - 2016/1
N2 - Background Oxidative stress has been reported to play an
important role in children with primary nephrotic syndrome
(PNS). However, the results of previous studies are
controversial.
Methods Forty children with steroid-sensitive nephrotic syndrome
(SSNS) and 20 age- and sex-matched healthy controls
were enrolled. Patients were followed-up for 12-18 months
and divided into three subgroups: frequent relapse (n=10),
non-frequent relapse (n=12), and non-relapse (n=18). The
plasma levels of advanced oxidation protein products
(AOPP), malondialdehyde (MDA), and superoxide dismutase
(SOD) were tested in controls and patient group at first presentation
and after 4 weeks of steroid treatment.
Results Patients had higher AOPP and MDA levels but lower
SOD compared with controls. AOPP levels were significantly
higher in the frequent relapse subgroup compared with the nonfrequent
relapse and non-relapse subgroups, respectively. No significant
differences were found in the plasma levels of MDA and
SOD among the three subgroups. AOPP >87.55 μmol/l before
steroid treatment and AOPP >78.5 μmol/l after 4-week steroid
treatment were positively correlated with the relapse frequency in
patients with SSNS.
Conclusions Children with SSNS have oxidative stress. The
plasma levels of AOPP before and after 4-week steroid treatment
may predict whether patients with SSNS will relapse
frequently.
AB - Background Oxidative stress has been reported to play an
important role in children with primary nephrotic syndrome
(PNS). However, the results of previous studies are
controversial.
Methods Forty children with steroid-sensitive nephrotic syndrome
(SSNS) and 20 age- and sex-matched healthy controls
were enrolled. Patients were followed-up for 12-18 months
and divided into three subgroups: frequent relapse (n=10),
non-frequent relapse (n=12), and non-relapse (n=18). The
plasma levels of advanced oxidation protein products
(AOPP), malondialdehyde (MDA), and superoxide dismutase
(SOD) were tested in controls and patient group at first presentation
and after 4 weeks of steroid treatment.
Results Patients had higher AOPP and MDA levels but lower
SOD compared with controls. AOPP levels were significantly
higher in the frequent relapse subgroup compared with the nonfrequent
relapse and non-relapse subgroups, respectively. No significant
differences were found in the plasma levels of MDA and
SOD among the three subgroups. AOPP >87.55 μmol/l before
steroid treatment and AOPP >78.5 μmol/l after 4-week steroid
treatment were positively correlated with the relapse frequency in
patients with SSNS.
Conclusions Children with SSNS have oxidative stress. The
plasma levels of AOPP before and after 4-week steroid treatment
may predict whether patients with SSNS will relapse
frequently.
KW - children
KW - steroid-sensitive nephrotic syndrome
KW - oxidative stress
KW - relapse
UR - http://www.ncbi.nlm.nih.gov/pubmed/26341250
U2 - 10.1007/s00467-015-3195-2
DO - 10.1007/s00467-015-3195-2
M3 - Article
VL - 31
SP - 83
EP - 88
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 1
ER -