Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

D. J. Cooper; K. R. Walley; P. M. Dodek; F. Rosenberg; J. A. Russell

doi:10.1007/BF01706475

Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

D. J. Cooper, K. R. Walley, P. M. Dodek, F. Rosenberg, J. A. Russell

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Abstract

Plasma ionized calcium [Ca⁺⁺] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO₂, [Ca⁺⁺], lactate, and albumin concentrations. We found a strong association between decreased [Ca⁺⁺] and increased plasma lactate concentrations (r²=0.78, p≤0.001). This unexpected association - [Ca⁺⁺] usually increases with increasing acidosis - might be clinically important and the mechanism deserves further investigation.

Original language	English
Pages (from-to)	286-289
Number of pages	4
Journal	Intensive Care Medicine
Volume	18
Issue number	5
DOIs	https://doi.org/10.1007/BF01706475
Publication status	Published - 1 May 1992

Keywords

Hypocalcemia
Ionized calcium
Lactate
Lactic acidosis

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10.1007/BF01706475

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title = "Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis",

abstract = "Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO2, [Ca++], lactate, and albumin concentrations. We found a strong association between decreased [Ca++] and increased plasma lactate concentrations (r2=0.78, p≤0.001). This unexpected association - [Ca++] usually increases with increasing acidosis - might be clinically important and the mechanism deserves further investigation.",

keywords = "Hypocalcemia, Ionized calcium, Lactate, Lactic acidosis",

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T1 - Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

AU - Cooper, D. J.

AU - Walley, K. R.

AU - Dodek, P. M.

AU - Rosenberg, F.

AU - Russell, J. A.

PY - 1992/5/1

Y1 - 1992/5/1

N2 - Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO2, [Ca++], lactate, and albumin concentrations. We found a strong association between decreased [Ca++] and increased plasma lactate concentrations (r2=0.78, p≤0.001). This unexpected association - [Ca++] usually increases with increasing acidosis - might be clinically important and the mechanism deserves further investigation.

AB - Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO2, [Ca++], lactate, and albumin concentrations. We found a strong association between decreased [Ca++] and increased plasma lactate concentrations (r2=0.78, p≤0.001). This unexpected association - [Ca++] usually increases with increasing acidosis - might be clinically important and the mechanism deserves further investigation.

KW - Hypocalcemia

KW - Ionized calcium

KW - Lactate

KW - Lactic acidosis

UR - https://www.scopus.com/pages/publications/0026667832

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SP - 286

EP - 289

JO - Intensive Care Medicine

JF - Intensive Care Medicine

IS - 5

ER -

Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

Abstract

Keywords

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