Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

D. J. Cooper; K. R. Walley; P. M. Dodek; F. Rosenberg; J. A. Russell

doi:10.1007/BF01706475

Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

D. J. Cooper, K. R. Walley, P. M. Dodek, F. Rosenberg, J. A. Russell

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Abstract

Plasma ionized calcium [Ca⁺⁺] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO₂, [Ca⁺⁺], lactate, and albumin concentrations. We found a strong association between decreased [Ca⁺⁺] and increased plasma lactate concentrations (r²=0.78, p≤0.001). This unexpected association - [Ca⁺⁺] usually increases with increasing acidosis - might be clinically important and the mechanism deserves further investigation.

Original language	English
Pages (from-to)	286-289
Number of pages	4
Journal	Intensive Care Medicine
Volume	18
Issue number	5
DOIs	https://doi.org/10.1007/BF01706475
Publication status	Published - 1 May 1992

Keywords

Hypocalcemia
Ionized calcium
Lactate
Lactic acidosis

Access to Document

10.1007/BF01706475

Cite this

@article{92074c5dec7d4ad0ada1c25d84f14cb7,

title = "Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis",

abstract = "Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO2, [Ca++], lactate, and albumin concentrations. We found a strong association between decreased [Ca++] and increased plasma lactate concentrations (r2=0.78, p≤0.001). This unexpected association - [Ca++] usually increases with increasing acidosis - might be clinically important and the mechanism deserves further investigation.",

keywords = "Hypocalcemia, Ionized calcium, Lactate, Lactic acidosis",

author = "Cooper, {D. J.} and Walley, {K. R.} and Dodek, {P. M.} and F. Rosenberg and Russell, {J. A.}",

year = "1992",

month = may,

day = "1",

doi = "10.1007/BF01706475",

language = "English",

volume = "18",

pages = "286--289",

journal = "Intensive Care Medicine",

issn = "0342-4642",

publisher = "Springer-Verlag London Ltd.",

number = "5",

}

TY - JOUR

T1 - Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

AU - Cooper, D. J.

AU - Walley, K. R.

AU - Dodek, P. M.

AU - Rosenberg, F.

AU - Russell, J. A.

PY - 1992/5/1

Y1 - 1992/5/1

N2 - Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO2, [Ca++], lactate, and albumin concentrations. We found a strong association between decreased [Ca++] and increased plasma lactate concentrations (r2=0.78, p≤0.001). This unexpected association - [Ca++] usually increases with increasing acidosis - might be clinically important and the mechanism deserves further investigation.

AB - Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO2, [Ca++], lactate, and albumin concentrations. We found a strong association between decreased [Ca++] and increased plasma lactate concentrations (r2=0.78, p≤0.001). This unexpected association - [Ca++] usually increases with increasing acidosis - might be clinically important and the mechanism deserves further investigation.

KW - Hypocalcemia

KW - Ionized calcium

KW - Lactate

KW - Lactic acidosis

UR - http://www.scopus.com/inward/record.url?scp=0026667832&partnerID=8YFLogxK

U2 - 10.1007/BF01706475

DO - 10.1007/BF01706475

M3 - Article

C2 - 1343563

AN - SCOPUS:0026667832

SN - 0342-4642

VL - 18

SP - 286

EP - 289

JO - Intensive Care Medicine

JF - Intensive Care Medicine

IS - 5

ER -

Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

Abstract

Keywords

Access to Document

Other files and links

Cite this