Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis

D. J. Cooper, K. R. Walley, P. M. Dodek, F. Rosenberg, J. A. Russell

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Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO2, [Ca++], lactate, and albumin concentrations. We found a strong association between decreased [Ca++] and increased plasma lactate concentrations (r2=0.78, p≤0.001). This unexpected association - [Ca++] usually increases with increasing acidosis - might be clinically important and the mechanism deserves further investigation.

Original languageEnglish
Pages (from-to)286-289
Number of pages4
JournalIntensive Care Medicine
Issue number5
Publication statusPublished - 1 May 1992


  • Hypocalcemia
  • Ionized calcium
  • Lactate
  • Lactic acidosis

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