TY - JOUR
T1 - Plasma interleukin-18 levels are a biomarker of innate immune responses that predict and characterize tuberculosis-associated immune reconstitution inflammatory syndrome
AU - Tan, Hong Yien
AU - Yong, Yean Kong
AU - Andrade, Bruno B
AU - Shankar, Esaki M
AU - Ponnampalavanar, Sasheela
AU - Omar, Sharifah Faridah Syed
AU - Narendran, Gopalan
AU - Kamarulzaman, Adeeba Binti
AU - Swaminathan, Soumya
AU - Sereti, Irini
AU - Crowe, Suzanne Mary
AU - French, Martyn A
PY - 2015
Y1 - 2015
N2 - BACKGROUND: : Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a substantial problem in HIV/TB coinfected patients commencing antiretroviral therapy (ART). The immunopathogenesis of TB-IRIS includes increased production of proinflammatory chemokines and cytokines, including interleukin-18, which is a signature cytokine of the nucleotide-binding domain and leucine-rich repeat pyrin containing protein-3 inflammasome. We compared plasma levels of interleukin-18 and other biomarkers of monocyte/macrophage activation in the prediction and characterization of TB-IRIS. METHODS: : Biomarkers were assayed pre-ART and during TB-IRIS, or equivalent time-point, in a case-control study of Malaysian HIV patients with paradoxical or unmasking TB-IRIS (n=15), TB no IRIS (n=14), and no TB or IRIS (n=15). Findings for interleukin-18 were verified in another cohort of patients with paradoxical TB-IRIS (n=26) and their controls (n=22) from India. RESULTS: : Interleukin-18 was higher in TB-IRIS patients pre-ART and during the event in both Malaysian patients (P
AB - BACKGROUND: : Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a substantial problem in HIV/TB coinfected patients commencing antiretroviral therapy (ART). The immunopathogenesis of TB-IRIS includes increased production of proinflammatory chemokines and cytokines, including interleukin-18, which is a signature cytokine of the nucleotide-binding domain and leucine-rich repeat pyrin containing protein-3 inflammasome. We compared plasma levels of interleukin-18 and other biomarkers of monocyte/macrophage activation in the prediction and characterization of TB-IRIS. METHODS: : Biomarkers were assayed pre-ART and during TB-IRIS, or equivalent time-point, in a case-control study of Malaysian HIV patients with paradoxical or unmasking TB-IRIS (n=15), TB no IRIS (n=14), and no TB or IRIS (n=15). Findings for interleukin-18 were verified in another cohort of patients with paradoxical TB-IRIS (n=26) and their controls (n=22) from India. RESULTS: : Interleukin-18 was higher in TB-IRIS patients pre-ART and during the event in both Malaysian patients (P
UR - http://journals.lww.com/aidsonline/pages/articleviewer.aspx?year=2015&issue=02200&article=00004&type=abstract
U2 - 10.1097/QAD.0000000000000557
DO - 10.1097/QAD.0000000000000557
M3 - Article
SN - 0269-9370
VL - 29
SP - 421
EP - 431
JO - AIDS
JF - AIDS
IS - 4
ER -
