Plasma follistatin concentration increase following lipopolysaccharide administration in sheep

Rudi Klein, Iain J. Clarke, Mark P. Hedger, David M. Robertson

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Abstract

1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plamsa follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-α concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response.

Original languageEnglish
Pages (from-to)754-755
Number of pages2
JournalClinical and Experimental Pharmacology and Physiology
Volume23
Issue number8
Publication statusPublished - 1996

Keywords

  • Activin
  • Follistatin
  • Lipopolysaccharide
  • Tumour necrosis factor-

Cite this

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abstract = "1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plamsa follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-α concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response.",
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Plasma follistatin concentration increase following lipopolysaccharide administration in sheep. / Klein, Rudi; Clarke, Iain J.; Hedger, Mark P.; Robertson, David M.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 23, No. 8, 1996, p. 754-755.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Klein, Rudi

AU - Clarke, Iain J.

AU - Hedger, Mark P.

AU - Robertson, David M.

PY - 1996

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N2 - 1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plamsa follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-α concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response.

AB - 1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plamsa follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-α concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response.

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KW - Follistatin

KW - Lipopolysaccharide

KW - Tumour necrosis factor-

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JF - Clinical and Experimental Pharmacology and Physiology

SN - 0305-1870

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