Plasma follistatin concentration increase following lipopolysaccharide administration in sheep

Rudi Klein, Iain J. Clarke, Mark P. Hedger, David M. Robertson

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Abstract

1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plamsa follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-α concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response.

Original languageEnglish
Pages (from-to)754-755
Number of pages2
JournalClinical and Experimental Pharmacology and Physiology
Volume23
Issue number8
Publication statusPublished - 1996

Keywords

  • Activin
  • Follistatin
  • Lipopolysaccharide
  • Tumour necrosis factor-

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