TY - JOUR
T1 - Plasma dihydroceramide species associate with waist circumference in Mexican American families
AU - Mamtani, Manju
AU - Meikle, Peter J.
AU - Kulkarni, Hemant
AU - Weir, Jacquelyn M
AU - Barlow, Christopher K.
AU - Jowett, Jeremy B M
AU - Bellis, Claire
AU - Dyer, Thomas D
AU - Almasy, Laura
AU - Mahaney, Michael C
AU - Duggirala, Ravindranath
AU - Comuzzie, Anthony G
AU - Blangero, John
AU - Curran, Joanne E
PY - 2014/3
Y1 - 2014/3
N2 - Objective Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. Methods Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software. Results After adjusting for age and sex interactions, body mass index, homeostasis model of assessment - insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18:0, 20:0, 22:0, and 24:1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31:1 and 41:1) were also associated with WC. Conclusions Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.
AB - Objective Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. Methods Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software. Results After adjusting for age and sex interactions, body mass index, homeostasis model of assessment - insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18:0, 20:0, 22:0, and 24:1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31:1 and 41:1) were also associated with WC. Conclusions Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.
UR - http://www.scopus.com/inward/record.url?scp=84895787748&partnerID=8YFLogxK
U2 - 10.1002/oby.20598
DO - 10.1002/oby.20598
M3 - Article
AN - SCOPUS:84895787748
SN - 1930-7381
VL - 22
SP - 950
EP - 956
JO - Obesity
JF - Obesity
IS - 3
M1 - https://doi.org/10.1002/oby.20598
ER -