Plasma dihydroceramide species associate with waist circumference in Mexican American families

Manju Mamtani, Peter J. Meikle, Hemant Kulkarni, Jacquelyn M Weir, Christopher K. Barlow, Jeremy B M Jowett, Claire Bellis, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Ravindranath Duggirala, Anthony G Comuzzie, John Blangero, Joanne E Curran

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21 Citations (Scopus)

Abstract

Objective Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. Methods Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software. Results After adjusting for age and sex interactions, body mass index, homeostasis model of assessment - insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18:0, 20:0, 22:0, and 24:1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31:1 and 41:1) were also associated with WC. Conclusions Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.

Original languageEnglish
Pages (from-to)950-956
Number of pages7
JournalObesity
Volume22
Issue number3
DOIs
Publication statusPublished - Mar 2014
Externally publishedYes

Cite this

Mamtani, Manju ; Meikle, Peter J. ; Kulkarni, Hemant ; Weir, Jacquelyn M ; Barlow, Christopher K. ; Jowett, Jeremy B M ; Bellis, Claire ; Dyer, Thomas D ; Almasy, Laura ; Mahaney, Michael C ; Duggirala, Ravindranath ; Comuzzie, Anthony G ; Blangero, John ; Curran, Joanne E. / Plasma dihydroceramide species associate with waist circumference in Mexican American families. In: Obesity. 2014 ; Vol. 22, No. 3. pp. 950-956.
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title = "Plasma dihydroceramide species associate with waist circumference in Mexican American families",
abstract = "Objective Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. Methods Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software. Results After adjusting for age and sex interactions, body mass index, homeostasis model of assessment - insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18:0, 20:0, 22:0, and 24:1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31:1 and 41:1) were also associated with WC. Conclusions Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.",
author = "Manju Mamtani and Meikle, {Peter J.} and Hemant Kulkarni and Weir, {Jacquelyn M} and Barlow, {Christopher K.} and Jowett, {Jeremy B M} and Claire Bellis and Dyer, {Thomas D} and Laura Almasy and Mahaney, {Michael C} and Ravindranath Duggirala and Comuzzie, {Anthony G} and John Blangero and Curran, {Joanne E}",
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Mamtani, M, Meikle, PJ, Kulkarni, H, Weir, JM, Barlow, CK, Jowett, JBM, Bellis, C, Dyer, TD, Almasy, L, Mahaney, MC, Duggirala, R, Comuzzie, AG, Blangero, J & Curran, JE 2014, 'Plasma dihydroceramide species associate with waist circumference in Mexican American families', Obesity, vol. 22, no. 3, pp. 950-956. https://doi.org/10.1002/oby.20598

Plasma dihydroceramide species associate with waist circumference in Mexican American families. / Mamtani, Manju; Meikle, Peter J.; Kulkarni, Hemant; Weir, Jacquelyn M; Barlow, Christopher K.; Jowett, Jeremy B M; Bellis, Claire; Dyer, Thomas D; Almasy, Laura; Mahaney, Michael C; Duggirala, Ravindranath ; Comuzzie, Anthony G; Blangero, John; Curran, Joanne E.

In: Obesity, Vol. 22, No. 3, 03.2014, p. 950-956.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Plasma dihydroceramide species associate with waist circumference in Mexican American families

AU - Mamtani, Manju

AU - Meikle, Peter J.

AU - Kulkarni, Hemant

AU - Weir, Jacquelyn M

AU - Barlow, Christopher K.

AU - Jowett, Jeremy B M

AU - Bellis, Claire

AU - Dyer, Thomas D

AU - Almasy, Laura

AU - Mahaney, Michael C

AU - Duggirala, Ravindranath

AU - Comuzzie, Anthony G

AU - Blangero, John

AU - Curran, Joanne E

PY - 2014/3

Y1 - 2014/3

N2 - Objective Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. Methods Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software. Results After adjusting for age and sex interactions, body mass index, homeostasis model of assessment - insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18:0, 20:0, 22:0, and 24:1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31:1 and 41:1) were also associated with WC. Conclusions Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.

AB - Objective Waist circumference (WC), the clinical marker of central obesity, is gaining popularity as a screening tool for type 2 diabetes (T2D). While there is epidemiologic evidence favoring the WC-T2D association, its biological substantiation is generally weak. Our objective was to determine the independent association of plasma lipid repertoire with WC. Methods Samples and data from the San Antonio Family Heart Study of 1208 Mexican Americans from 42 extended families were used. Association of plasma lipidomic profiles with the cross-sectionally assessed WC was determined. Plasma lipidomic profiling entailed liquid chromatography with mass spectrometry. Statistical analyses included multivariable polygenic regression models and bivariate trait analyses using the SOLAR software. Results After adjusting for age and sex interactions, body mass index, homeostasis model of assessment - insulin resistance, total cholesterol, triglycerides, high density lipoproteins and use of lipid lowering drugs, dihydroceramides as a class were associated with WC. Dihydroceramide species 18:0, 20:0, 22:0, and 24:1 were significantly associated and genetically correlated with WC. Two sphingomyelin species (31:1 and 41:1) were also associated with WC. Conclusions Plasma dihydroceramide levels independently associate with WC. Thus, high resolution plasma lipidomic studies can provide further credence to the biological underpinnings of the association of WC with T2D.

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U2 - 10.1002/oby.20598

DO - 10.1002/oby.20598

M3 - Article

VL - 22

SP - 950

EP - 956

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JF - Obesity

SN - 1930-7381

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