Plasma concentrations of propranolol and 4‐hydroxypropranolol during chronic oral propranolol therapy.

L. Wong, RL Nation, WL Chiou, PK Mehta

Research output: Contribution to journalArticleResearchpeer-review

Abstract

1 The plasma levels of propranolol and 4‐hydroxypropranolol have been measured in 17 hypertensive patients receiving chronic oral therapy with propranolol. 2 The range of plasma propranolol concentrations was from 5.3 to 300 ng/ml, and that of 4‐hydroxypropranolol was from 2.1 to 36.0 ng/ml. 3 The mean (+/‐ s.d.) plasma concentration ratio of 4‐ hydroxypropranolol to propranolol was 0.130 (+/‐ 0.005); however, a very wide range was observed with individual values ranging from 0.057 to 0.241. 4 A statistically significant correlation was observed between the plasma concentration of 4‐hydroxypropranolol and that of propranolol. 5 Propranolol and 4‐hydroxypropranolol plasma concentrations were each significantly, but poorly, correlated with daily propranolol dose. 6 The clinical significance of the results has been discussed. 1979 The British Pharmacological Society

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalBritish Journal of Clinical Pharmacology
Volume8
Issue number2
DOIs
Publication statusPublished - 1 Jan 1979

Cite this

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title = "Plasma concentrations of propranolol and 4‐hydroxypropranolol during chronic oral propranolol therapy.",
abstract = "1 The plasma levels of propranolol and 4‐hydroxypropranolol have been measured in 17 hypertensive patients receiving chronic oral therapy with propranolol. 2 The range of plasma propranolol concentrations was from 5.3 to 300 ng/ml, and that of 4‐hydroxypropranolol was from 2.1 to 36.0 ng/ml. 3 The mean (+/‐ s.d.) plasma concentration ratio of 4‐ hydroxypropranolol to propranolol was 0.130 (+/‐ 0.005); however, a very wide range was observed with individual values ranging from 0.057 to 0.241. 4 A statistically significant correlation was observed between the plasma concentration of 4‐hydroxypropranolol and that of propranolol. 5 Propranolol and 4‐hydroxypropranolol plasma concentrations were each significantly, but poorly, correlated with daily propranolol dose. 6 The clinical significance of the results has been discussed. 1979 The British Pharmacological Society",
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Plasma concentrations of propranolol and 4‐hydroxypropranolol during chronic oral propranolol therapy. / Wong, L.; Nation, RL; Chiou, WL; Mehta, PK.

In: British Journal of Clinical Pharmacology, Vol. 8, No. 2, 01.01.1979, p. 163-167.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Wong, L.

AU - Nation, RL

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N2 - 1 The plasma levels of propranolol and 4‐hydroxypropranolol have been measured in 17 hypertensive patients receiving chronic oral therapy with propranolol. 2 The range of plasma propranolol concentrations was from 5.3 to 300 ng/ml, and that of 4‐hydroxypropranolol was from 2.1 to 36.0 ng/ml. 3 The mean (+/‐ s.d.) plasma concentration ratio of 4‐ hydroxypropranolol to propranolol was 0.130 (+/‐ 0.005); however, a very wide range was observed with individual values ranging from 0.057 to 0.241. 4 A statistically significant correlation was observed between the plasma concentration of 4‐hydroxypropranolol and that of propranolol. 5 Propranolol and 4‐hydroxypropranolol plasma concentrations were each significantly, but poorly, correlated with daily propranolol dose. 6 The clinical significance of the results has been discussed. 1979 The British Pharmacological Society

AB - 1 The plasma levels of propranolol and 4‐hydroxypropranolol have been measured in 17 hypertensive patients receiving chronic oral therapy with propranolol. 2 The range of plasma propranolol concentrations was from 5.3 to 300 ng/ml, and that of 4‐hydroxypropranolol was from 2.1 to 36.0 ng/ml. 3 The mean (+/‐ s.d.) plasma concentration ratio of 4‐ hydroxypropranolol to propranolol was 0.130 (+/‐ 0.005); however, a very wide range was observed with individual values ranging from 0.057 to 0.241. 4 A statistically significant correlation was observed between the plasma concentration of 4‐hydroxypropranolol and that of propranolol. 5 Propranolol and 4‐hydroxypropranolol plasma concentrations were each significantly, but poorly, correlated with daily propranolol dose. 6 The clinical significance of the results has been discussed. 1979 The British Pharmacological Society

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