Plasma carbamazepine determinations: A simple gas chromatographic method

O. Drummer, P. Morris, F. Vajda

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Abstract

1. A simple, rapid and specific gas chromatographic method for the measurement of plasma carbamazepine concentration is presented. 2. The extraction is a single step method, and the drug is measured by derivatization using on column methylation and standard instrumentation. 3. Other anticonvulsant agents do not co‐extract. Other drugs do not interfere in the chromatogram. 4. Stability, recovery and reproducibility make this procedure suitable for routine carbamazepine measurements.

Original languageEnglish
Pages (from-to)497-501
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume3
Issue number5
DOIs
Publication statusPublished - Oct 1976
Externally publishedYes

Keywords

  • carbamazepine
  • GLC
  • plasma.

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