Plasma biomarkers for brain injury in extracorporeal membrane oxygenation

Shrey Kapoor; Anna Kolchinski; Aaron M. Gusdon; Lavienraj Premraj; Sung Min Cho

doi:10.4266/acc.2023.01368

Plasma biomarkers for brain injury in extracorporeal membrane oxygenation

Shrey Kapoor
, Anna Kolchinski
, Aaron M. Gusdon
, Lavienraj Premraj
, Sung Min Cho

Research output: Contribution to journal › Review Article › Other › peer-review

2 Citations (Scopus)

Abstract

Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients with refractory cardiorespiratory failure. Despite its benefits, ECMO carries a significant risk of neurological complications, including acute brain injury (ABI). Although standardized neuromonitoring and neurological care have been shown to improve early detection of ABI, the inability to perform neuroimaging in a timely manner is a major limitation in the accurate diagnosis of neurological complications. Therefore, blood-based biomarkers capable of detecting ongoing brain injury at the bedside are of great clinical significance. This review aims to provide a concise review of the current literature on plasma biomarkers for ABI in patients on ECMO support.

Original language	English
Pages (from-to)	389-398
Number of pages	10
Journal	Acute and Critical Care
Volume	38
Issue number	4
DOIs	https://doi.org/10.4266/acc.2023.01368
Publication status	Published - Nov 2023
Externally published	Yes

Keywords

acute brain injury
biomarkers
extracorporeal membrane oxygenation

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10.4266/acc.2023.01368Licence: CC BY-NC

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title = "Plasma biomarkers for brain injury in extracorporeal membrane oxygenation",

abstract = "Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients with refractory cardiorespiratory failure. Despite its benefits, ECMO carries a significant risk of neurological complications, including acute brain injury (ABI). Although standardized neuromonitoring and neurological care have been shown to improve early detection of ABI, the inability to perform neuroimaging in a timely manner is a major limitation in the accurate diagnosis of neurological complications. Therefore, blood-based biomarkers capable of detecting ongoing brain injury at the bedside are of great clinical significance. This review aims to provide a concise review of the current literature on plasma biomarkers for ABI in patients on ECMO support.",

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AU - Kapoor, Shrey

AU - Kolchinski, Anna

AU - Gusdon, Aaron M.

AU - Premraj, Lavienraj

AU - Cho, Sung Min

PY - 2023/11

Y1 - 2023/11

N2 - Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients with refractory cardiorespiratory failure. Despite its benefits, ECMO carries a significant risk of neurological complications, including acute brain injury (ABI). Although standardized neuromonitoring and neurological care have been shown to improve early detection of ABI, the inability to perform neuroimaging in a timely manner is a major limitation in the accurate diagnosis of neurological complications. Therefore, blood-based biomarkers capable of detecting ongoing brain injury at the bedside are of great clinical significance. This review aims to provide a concise review of the current literature on plasma biomarkers for ABI in patients on ECMO support.

AB - Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients with refractory cardiorespiratory failure. Despite its benefits, ECMO carries a significant risk of neurological complications, including acute brain injury (ABI). Although standardized neuromonitoring and neurological care have been shown to improve early detection of ABI, the inability to perform neuroimaging in a timely manner is a major limitation in the accurate diagnosis of neurological complications. Therefore, blood-based biomarkers capable of detecting ongoing brain injury at the bedside are of great clinical significance. This review aims to provide a concise review of the current literature on plasma biomarkers for ABI in patients on ECMO support.

KW - acute brain injury

KW - biomarkers

KW - extracorporeal membrane oxygenation

UR - https://www.scopus.com/pages/publications/85179996123

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DO - 10.4266/acc.2023.01368

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VL - 38

SP - 389

EP - 398

JO - Acute and Critical Care

JF - Acute and Critical Care

IS - 4

ER -

Plasma biomarkers for brain injury in extracorporeal membrane oxygenation

Abstract

Keywords

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