Purpose of review To summarize the impact of lowering LDL-C on plaque progression, microstructures and compositions. Recent findings Low-density lipoprotein cholesterol (LDL-C) is a major therapeutic target to prevent atherosclerotic cardiovascular disease. Intravascular imaging has elucidated antiatherosclerotic effects of lowering LDL-C in vivo. Intensive control of LDL-C with a statin has been shown to slow plaque progression and induce its regression if very low LDL-C level is achieved. This therapeutic approach has been also demonstrated to modulate plaque microstructures and compositions. These mechanistic insights on intravascular imaging support the benefit of lowering LDL-C in achieving better cardiovascular outcomes. Summary Lowering LDL-C level has become the first-line therapy in the primary and secondary prevention settings. The effects of lowering LDL-C on plaque progression, microstructures and compositions will be reviewed in this article.
|Number of pages||11|
|Journal||Current Opinion in Endocrinology, Diabetes and Obesity|
|Publication status||Published - 1 Jan 2017|
- Intravascular imaging
- Low-density lipoprotein cholesterol
- Plaque microstructures