Plaque burden, microstructures and compositions underachieving very low LDL-C levels

Yu Kataoka, Jordan Andrews, Rishi Puri, Peter J. Psaltis, Stephen J. Nicholls

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)


Purpose of review To summarize the impact of lowering LDL-C on plaque progression, microstructures and compositions. Recent findings Low-density lipoprotein cholesterol (LDL-C) is a major therapeutic target to prevent atherosclerotic cardiovascular disease. Intravascular imaging has elucidated antiatherosclerotic effects of lowering LDL-C in vivo. Intensive control of LDL-C with a statin has been shown to slow plaque progression and induce its regression if very low LDL-C level is achieved. This therapeutic approach has been also demonstrated to modulate plaque microstructures and compositions. These mechanistic insights on intravascular imaging support the benefit of lowering LDL-C in achieving better cardiovascular outcomes. Summary Lowering LDL-C level has become the first-line therapy in the primary and secondary prevention settings. The effects of lowering LDL-C on plaque progression, microstructures and compositions will be reviewed in this article.

Original languageEnglish
Pages (from-to)122-132
Number of pages11
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Issue number2
Publication statusPublished - 1 Jan 2017
Externally publishedYes


  • Intravascular imaging
  • Low-density lipoprotein cholesterol
  • Plaque microstructures

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