Plant terpenoids as the promising source of cholinesterase inhibitors for anti-AD therapy

Shereen Lai Shi Min; Sook Yee Liew; Nelson Jeng Yeou Chear; Bey Hing Goh; Wen Nee Tan; Kooi Yeong Khaw

doi:10.3390/biology11020307

Plant terpenoids as the promising source of cholinesterase inhibitors for anti-AD therapy

Shereen Lai Shi Min, Sook Yee Liew, Nelson Jeng Yeou Chear, Bey Hing Goh, Wen Nee Tan, Kooi Yeong Khaw

Malaysia Sch of Pharmacy

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections. There are research interests in recent years on terpene-derived metabolites (diterpenes, triterpenes and sesquiterpenes), which are believed to serve as excellent cholinesterase inhibitors. As cholinesterase inhibitors are the current treatment for Alzheimer’s disease, terpene-derived metabolites will have the potential to be involved in the future drug development for Alzheimer’s disease. Hence, a bibliographic search was conducted by using the keywords “terpene”, “cholinesterase” and “Alzheimer’s disease”, along with cross-referencing from 2011 to 2020, to provide an overview of natural terpenes with potential anticholinesterase properties. This review focuses on the extraction, chemical structures and anti-cholinesterase mechanisms of terpenes, which support and encourage future research on drug discovery and development in treating Alzheimer’s disease.

Original language	English
Article number	307
Number of pages	16
Journal	Biology
Volume	11
Issue number	2
DOIs	https://doi.org/10.3390/biology11020307
Publication status	Published - Feb 2022

Keywords

Alzheimer’s disease
Cholinesterase
Nor-abietanoid
Serratene
Terpene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/biology11020307Licence: CC BY

378398217-oaFinal published version, 2.88 MBLicence: CC BY

Cite this

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title = "Plant terpenoids as the promising source of cholinesterase inhibitors for anti-AD therapy",

abstract = "Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections. There are research interests in recent years on terpene-derived metabolites (diterpenes, triterpenes and sesquiterpenes), which are believed to serve as excellent cholinesterase inhibitors. As cholinesterase inhibitors are the current treatment for Alzheimer{\textquoteright}s disease, terpene-derived metabolites will have the potential to be involved in the future drug development for Alzheimer{\textquoteright}s disease. Hence, a bibliographic search was conducted by using the keywords “terpene”, “cholinesterase” and “Alzheimer{\textquoteright}s disease”, along with cross-referencing from 2011 to 2020, to provide an overview of natural terpenes with potential anticholinesterase properties. This review focuses on the extraction, chemical structures and anti-cholinesterase mechanisms of terpenes, which support and encourage future research on drug discovery and development in treating Alzheimer{\textquoteright}s disease.",

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author = "Min, {Shereen Lai Shi} and Liew, {Sook Yee} and Chear, {Nelson Jeng Yeou} and Goh, {Bey Hing} and Tan, {Wen Nee} and Khaw, {Kooi Yeong}",

note = "Funding Information: This research was funded by the Ministry of Higher Education Malaysia for Fundamental Research Grant Scheme, with project code FRGS/1/2021/SKK0/MUSM/03/8; and School of Pharmacy, Monash University Malaysia, grant number STG-000039. Funding Information: Acknowledgments: The authors would like to acknowledge Monash University Malaysia and Universiti Sains Malaysia for facilities and support. We would also like to acknowledge Universiti Sains Malaysia for the funding support. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Min, Shereen Lai Shi

AU - Liew, Sook Yee

AU - Chear, Nelson Jeng Yeou

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AU - Tan, Wen Nee

AU - Khaw, Kooi Yeong

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PY - 2022/2

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N2 - Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections. There are research interests in recent years on terpene-derived metabolites (diterpenes, triterpenes and sesquiterpenes), which are believed to serve as excellent cholinesterase inhibitors. As cholinesterase inhibitors are the current treatment for Alzheimer’s disease, terpene-derived metabolites will have the potential to be involved in the future drug development for Alzheimer’s disease. Hence, a bibliographic search was conducted by using the keywords “terpene”, “cholinesterase” and “Alzheimer’s disease”, along with cross-referencing from 2011 to 2020, to provide an overview of natural terpenes with potential anticholinesterase properties. This review focuses on the extraction, chemical structures and anti-cholinesterase mechanisms of terpenes, which support and encourage future research on drug discovery and development in treating Alzheimer’s disease.

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Plant terpenoids as the promising source of cholinesterase inhibitors for anti-AD therapy

Abstract

Keywords

UN SDGs

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Other files and links

Deciphering the potential of prenylated xanthones as a potential neuroprotective agent for Alzheimer's disease using cellular and Caenorhabditis elegans models

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Plant terpenoids as the promising source of cholinesterase inhibitors for anti-AD therapy

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Deciphering the potential of prenylated xanthones as a potential neuroprotective agent for Alzheimer's disease using cellular and Caenorhabditis elegans models

Cite this