Plant-derived antimicrobials: Insights into mitigation of antimicrobial resistance

Shun Kai Yang, Lee Yoon Low, Polly Soo Xi Yap, Khatijah Yusoff, Chun Wai Mai, Kok Song Lai, Swee Hua Erin Lim

Research output: Contribution to journalReview ArticleResearchpeer-review

26 Citations (Scopus)

Abstract

Antibiotic resistance had first been reported not long after the discovery of the first antibiotic and has remained a major public health issue ever since. Challenges are constantly encountered during the mitigation process of antibiotic resistance in the clinical setting; especially with the emergence of the formidable superbug, a bacteria with multiple resistance towards different antibiotics; this resulted in the term multidrug resistant (MDR) bacteria. This rapid evolution of the resistance phenomenon has propelled researchers to continuously uncover new antimicrobial agents in a bid to hopefully, downplay the rate of evolution despite a drying pipeline. Recently, there has been a paradigm shift in the mining of potential antimicrobials; in the past, targets for drug discovery were from microorganisms and at current, the focus has moved onto plants, this is mainly due to the beneficial attributes that plants are able to confer over that of microorganisms. This review will briefly discuss antibiotic resistance mechanisms employed by resistant bacteria followed by a detailed expository regarding the use of secondary metabolites from plants as a potential solution to the MDR pathogen. Finally, future prospects recommending enhancements to the usage of plant secondary metabolites to directly target antibiotic resistant pathogens will be discussed.

Original languageEnglish
Pages (from-to)295-316
Number of pages22
JournalRecords of Natural Products
Volume12
Issue number4
DOIs
Publication statusPublished - 2018
Externally publishedYes

Keywords

  • Antimicrobial resistance
  • Plant metabolites
  • Resistance reversal
  • Synergism

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