Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia

Clare Whitehead, Kirsten Palmer, Ulrika Nilsson, Yan Gao, Burcu Saglam, Martha Lappas, Stephen Tong

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25 Citations (Scopus)

Abstract

Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia. BJOG 2011; DOI: 10.1111/j.1471-0528.2011.02962.x. sFlt-1 is increased in the placenta and serum of women with pre-eclampsia. A novel primate-specific splice variant has recently been discovered, but its expression in severe pre-eclampsia has yet to be reported. We investigated placental expression of the previously described variant, sFlt-1/sFlt-i13, and the novel variant, sFlt-e15a, in pregnancies complicated by severe early onset pre-eclampsia (n = 14) and HELLP (haemolysis, elevated liver enzymes and a low platelet count) syndrome (n = 8). There was significant upregulation of both variants in pre-eclampsia and HELLP syndrome compared with normotensive term (n = 35) and preterm controls (n = 8). We conclude that the novel primate-specific splice variant of sFlt-1 is highly expressed in both severe pre-eclampsia and HELLP.
Original languageEnglish
Pages (from-to)1268 - 1271
Number of pages4
JournalBJOG: an International Journal of Obstetrics and Gynaecology
Volume118
Issue number10
DOIs
Publication statusPublished - 2011

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