Placenta-specific methylation of the vitamin D 24-hydroxylase gene. Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface

Boris Novakovic; Mandy Sibson; Hong Kiat Ng; Ursula Chandini Manuelpillai; Vardhman Rakyan; Thomas Down; Stephan Beck; Thierry Fournier; Danielle Evain-Brion; Eva Dimitriadis; Jeffrey M Craig; Ruth Morley; Richard Saffery

Placenta-specific methylation of the vitamin D 24-hydroxylase gene. Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface

Boris Novakovic, Mandy Sibson, Hong Kiat Ng, Ursula Chandini Manuelpillai, Vardhman Rakyan, Thomas Down, Stephan Beck, Thierry Fournier, Danielle Evain-Brion, Eva Dimitriadis, Jeffrey M Craig, Ruth Morley, Richard Saffery

Hudson Institute - Department of Molecular and Translational Science

Research output: Contribution to journal › Article › Research › peer-review

222 Citations (Scopus)

Abstract

In this study, we investigated the methylation status of genes regulating vitamin D bioavailability and activity in the placenta. No methylation of the VDR (vitamin D receptor) and CYP27B1 genes was found in any placental tissues. In contrast, the CYP24A1 gene is methylated in human placenta, purified cytotrophoblasts, and primary and cultured chorionic villus sampling tissue

Original language	English
Pages (from-to)	14838 - 14848
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	284
Issue number	22
Publication status	Published - 2009

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Novakovic, B., Sibson, M., Ng, H. K., Manuelpillai, U. C., Rakyan, V., Down, T., Beck, S., Fournier, T., Evain-Brion, D., Dimitriadis, E., Craig, J. M., Morley, R., & Saffery, R. (2009). Placenta-specific methylation of the vitamin D 24-hydroxylase gene. Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. Journal of Biological Chemistry, 284(22), 14838 - 14848.

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title = "Placenta-specific methylation of the vitamin D 24-hydroxylase gene. Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface",

abstract = "In this study, we investigated the methylation status of genes regulating vitamin D bioavailability and activity in the placenta. No methylation of the VDR (vitamin D receptor) and CYP27B1 genes was found in any placental tissues. In contrast, the CYP24A1 gene is methylated in human placenta, purified cytotrophoblasts, and primary and cultured chorionic villus sampling tissue",

author = "Boris Novakovic and Mandy Sibson and Ng, {Hong Kiat} and Manuelpillai, {Ursula Chandini} and Vardhman Rakyan and Thomas Down and Stephan Beck and Thierry Fournier and Danielle Evain-Brion and Eva Dimitriadis and Craig, {Jeffrey M} and Ruth Morley and Richard Saffery",

year = "2009",

language = "English",

volume = "284",

pages = "14838 -- 14848",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

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Novakovic, B, Sibson, M, Ng, HK, Manuelpillai, UC, Rakyan, V, Down, T, Beck, S, Fournier, T, Evain-Brion, D, Dimitriadis, E, Craig, JM, Morley, R & Saffery, R 2009, 'Placenta-specific methylation of the vitamin D 24-hydroxylase gene. Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface', Journal of Biological Chemistry, vol. 284, no. 22, pp. 14838 - 14848.

Placenta-specific methylation of the vitamin D 24-hydroxylase gene. Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. / Novakovic, Boris; Sibson, Mandy; Ng, Hong Kiat et al.
In: Journal of Biological Chemistry, Vol. 284, No. 22, 2009, p. 14838 - 14848.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Placenta-specific methylation of the vitamin D 24-hydroxylase gene. Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface

AU - Novakovic, Boris

AU - Sibson, Mandy

AU - Ng, Hong Kiat

AU - Manuelpillai, Ursula Chandini

AU - Rakyan, Vardhman

AU - Down, Thomas

AU - Beck, Stephan

AU - Fournier, Thierry

AU - Evain-Brion, Danielle

AU - Dimitriadis, Eva

AU - Craig, Jeffrey M

AU - Morley, Ruth

AU - Saffery, Richard

PY - 2009

Y1 - 2009

N2 - In this study, we investigated the methylation status of genes regulating vitamin D bioavailability and activity in the placenta. No methylation of the VDR (vitamin D receptor) and CYP27B1 genes was found in any placental tissues. In contrast, the CYP24A1 gene is methylated in human placenta, purified cytotrophoblasts, and primary and cultured chorionic villus sampling tissue

AB - In this study, we investigated the methylation status of genes regulating vitamin D bioavailability and activity in the placenta. No methylation of the VDR (vitamin D receptor) and CYP27B1 genes was found in any placental tissues. In contrast, the CYP24A1 gene is methylated in human placenta, purified cytotrophoblasts, and primary and cultured chorionic villus sampling tissue

UR - http://www.jbc.org/content/284/22/14838.full.pdf+html

M3 - Article

SN - 0021-9258

VL - 284

SP - 14838

EP - 14848

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 22

ER -

Placenta-specific methylation of the vitamin D 24-hydroxylase gene. Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface

Abstract

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