Placenta-specific methylation of the vitamin D 24-hydroxylase gene. Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface

Boris Novakovic, Mandy Sibson, Hong Kiat Ng, Ursula Chandini Manuelpillai, Vardhman Rakyan, Thomas Down, Stephan Beck, Thierry Fournier, Danielle Evain-Brion, Eva Dimitriadis, Jeffrey M Craig, Ruth Morley, Richard Saffery

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Abstract

In this study, we investigated the methylation status of genes regulating vitamin D bioavailability and activity in the placenta. No methylation of the VDR (vitamin D receptor) and CYP27B1 genes was found in any placental tissues. In contrast, the CYP24A1 gene is methylated in human placenta, purified cytotrophoblasts, and primary and cultured chorionic villus sampling tissue
Original languageEnglish
Pages (from-to)14838 - 14848
Number of pages11
JournalJournal of Biological Chemistry
Volume284
Issue number22
Publication statusPublished - 2009

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