TY - JOUR
T1 - Pioneering biosensor approaches for oral squamous cell carcinoma diagnosis
T2 - A comprehensive review
AU - Teow, Jun Yao
AU - Zhang, Qinyi
AU - Abidin, Syafiq Asnawi Zainal
AU - Tan, Chuey Chuan
AU - Abdul Rahman, Syarifah Nur Syed
AU - Karsani, Saiful Anuar
AU - Othman, Iekhsan
AU - Chen, Yeng
AU - Lakshmipriya, Thangavel
AU - Gopinath, Subash C.B.
N1 - Funding Information:
This research was funded by Universiti Malaya Impact-Oriented Interdisciplinary Research Grant Programme (IIRG) grant number IIRG002A-2021FNW.
Publisher Copyright:
© 2024 Elsevier Ltd
PY - 2024/6
Y1 - 2024/6
N2 - Oral squamous cell carcinoma (OSCC) remains a significant global challenge in the medical field, accounting for approximately 300,000 incidences and 145,000 mortalities annually. Studies suggest that early cancer detection is the most vital factor in improving OSCC patient outcomes. Effective clinical diagnosis methods for early OSCC are needed urgently. OSCC biomarkers are identified to be associated with cancer progression and biosensors are devices developed to detect the presence of OSCC biomarkers to allow early cancer diagnosis. Biosensor technology has significant potential in providing rapid and accurate detection of OSCC biomarkers with high sensitivity and specificity. Biosensors have various advantages compared to conventional diagnostic methods such as being non-invasive, low-cost, and convenient. Biosensors hold the potential to be adopted as point-of-care-testing (POCT) devices by bringing biosensor technology to the patients. This review aims to provide a comprehensive review by describing and comparing different categories of OSCC biosensors based on their advantages and drawbacks. The recent obstacles and opportunities for developing effective biosensors for cancer diagnosis are summarized.
AB - Oral squamous cell carcinoma (OSCC) remains a significant global challenge in the medical field, accounting for approximately 300,000 incidences and 145,000 mortalities annually. Studies suggest that early cancer detection is the most vital factor in improving OSCC patient outcomes. Effective clinical diagnosis methods for early OSCC are needed urgently. OSCC biomarkers are identified to be associated with cancer progression and biosensors are devices developed to detect the presence of OSCC biomarkers to allow early cancer diagnosis. Biosensor technology has significant potential in providing rapid and accurate detection of OSCC biomarkers with high sensitivity and specificity. Biosensors have various advantages compared to conventional diagnostic methods such as being non-invasive, low-cost, and convenient. Biosensors hold the potential to be adopted as point-of-care-testing (POCT) devices by bringing biosensor technology to the patients. This review aims to provide a comprehensive review by describing and comparing different categories of OSCC biosensors based on their advantages and drawbacks. The recent obstacles and opportunities for developing effective biosensors for cancer diagnosis are summarized.
KW - Biomarker
KW - Nanomaterial
KW - Oral carcinoma
KW - Post-translational modifications
UR - http://www.scopus.com/inward/record.url?scp=85188028167&partnerID=8YFLogxK
U2 - 10.1016/j.procbio.2024.02.015
DO - 10.1016/j.procbio.2024.02.015
M3 - Review Article
AN - SCOPUS:85188028167
SN - 1359-5113
VL - 141
SP - 71
EP - 81
JO - Process Biochemistry
JF - Process Biochemistry
ER -
