PIM activity in tumours: A key node of therapy resistance

Richard J. Rebello; Alisée V. Huglo; Luc Furic

doi:10.1016/j.jbior.2017.10.010

PIM activity in tumours: A key node of therapy resistance

Richard J. Rebello, Alisée V. Huglo, Luc Furic

Research output: Contribution to journal › Review Article › Research › peer-review

16 Citations (Scopus)

Abstract

The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.

Original language	English
Pages (from-to)	163-169
Number of pages	7
Journal	Advances in Biological Regulation
Volume	67
DOIs	https://doi.org/10.1016/j.jbior.2017.10.010
Publication status	Published - Jan 2018

Keywords

AKT
Breast
Cancer
MRNA translation
MTOR
MYC
PIM
Prostate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jbior.2017.10.010

Cite this

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title = "PIM activity in tumours: A key node of therapy resistance",

abstract = "The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.",

keywords = "AKT, Breast, Cancer, MRNA translation, MTOR, MYC, PIM, Prostate",

author = "Rebello, {Richard J.} and Huglo, {Alis{\'e}e V.} and Luc Furic",

year = "2018",

month = jan,

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language = "English",

volume = "67",

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journal = "Advances in Biological Regulation",

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T2 - A key node of therapy resistance

AU - Rebello, Richard J.

AU - Huglo, Alisée V.

AU - Furic, Luc

PY - 2018/1

Y1 - 2018/1

N2 - The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.

AB - The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.

KW - AKT

KW - Breast

KW - Cancer

KW - MRNA translation

KW - MTOR

KW - MYC

KW - PIM

KW - Prostate

UR - http://www.scopus.com/inward/record.url?scp=85032205972&partnerID=8YFLogxK

U2 - 10.1016/j.jbior.2017.10.010

DO - 10.1016/j.jbior.2017.10.010

M3 - Review Article

AN - SCOPUS:85032205972

VL - 67

SP - 163

EP - 169

JO - Advances in Biological Regulation

JF - Advances in Biological Regulation

SN - 2212-4926

ER -

PIM activity in tumours: A key node of therapy resistance

Abstract

Keywords

UN SDGs

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