PIM activity in tumours: A key node of therapy resistance

Richard J. Rebello; Alisée V. Huglo; Luc Furic

doi:10.1016/j.jbior.2017.10.010

PIM activity in tumours: A key node of therapy resistance

Richard J. Rebello, Alisée V. Huglo, Luc Furic

Research output: Contribution to journal › Review Article › Research › peer-review

9 Citations (Scopus)

Abstract

The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.

Original language	English
Pages (from-to)	163-169
Number of pages	7
Journal	Advances in Biological Regulation
Volume	67
DOIs	https://doi.org/10.1016/j.jbior.2017.10.010
Publication status	Published - Jan 2018

Keywords

AKT
Breast
Cancer
MRNA translation
MTOR
MYC
PIM
Prostate

Access to Document

10.1016/j.jbior.2017.10.010

Link to publication in Scopus

Cite this

Rebello, R. J., Huglo, A. V., & Furic, L. (2018). PIM activity in tumours: A key node of therapy resistance. Advances in Biological Regulation, 67, 163-169. https://doi.org/10.1016/j.jbior.2017.10.010

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