Abstract
The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.
| Original language | English |
|---|---|
| Pages (from-to) | 163-169 |
| Number of pages | 7 |
| Journal | Advances in Biological Regulation |
| Volume | 67 |
| DOIs | |
| Publication status | Published - Jan 2018 |
Keywords
- AKT
- Breast
- Cancer
- MRNA translation
- MTOR
- MYC
- PIM
- Prostate
Cite this
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PIM activity in tumours : A key node of therapy resistance. / Rebello, Richard J.; Huglo, Alisée V.; Furic, Luc.
In: Advances in Biological Regulation, Vol. 67, 01.2018, p. 163-169.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - PIM activity in tumours
T2 - A key node of therapy resistance
AU - Rebello, Richard J.
AU - Huglo, Alisée V.
AU - Furic, Luc
PY - 2018/1
Y1 - 2018/1
N2 - The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.
AB - The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.
KW - AKT
KW - Breast
KW - Cancer
KW - MRNA translation
KW - MTOR
KW - MYC
KW - PIM
KW - Prostate
UR - http://www.scopus.com/inward/record.url?scp=85032205972&partnerID=8YFLogxK
U2 - 10.1016/j.jbior.2017.10.010
DO - 10.1016/j.jbior.2017.10.010
M3 - Review Article
VL - 67
SP - 163
EP - 169
JO - Advances in Biological Regulation
JF - Advances in Biological Regulation
SN - 2212-4926
ER -