PIM activity in tumours: A key node of therapy resistance

Richard J. Rebello, Alisée V. Huglo, Luc Furic

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

Abstract

The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalAdvances in Biological Regulation
Volume67
DOIs
Publication statusPublished - Jan 2018

Keywords

  • AKT
  • Breast
  • Cancer
  • MRNA translation
  • MTOR
  • MYC
  • PIM
  • Prostate

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