Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery

Christian Albert; Johanna Kube; Anja Haase-Fielitz; Annemarie Dittrich; Denny Schanze; Martin Zenker; Hermann Kuppe; Roland Hetzer; Rinaldo Bellomo; Peter R. Mertens; Michael Haase

doi:10.2217/bmm.14.85

Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery

Christian Albert, Johanna Kube, Anja Haase-Fielitz, Annemarie Dittrich, Denny Schanze, Martin Zenker, Hermann Kuppe, Roland Hetzer, Rinaldo Bellomo, Peter R. Mertens, Michael Haase

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Aim: To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery. Patients & methods: We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, neutrophil gelatinase-associated lipocalin and midkine. We analyzed the association between such polymorphisms and these kidney-related variables. Results: Nonsignificantly more COMT LL patients developed RIFLE-AKI compared with non-LL patients (p = 0.11). Compared with HL and HH patients, LL patients who developed AKI had lower increases in serum creatinine. COMT LL patients had less pronounced release of tubular stress biomarkers (neutrophil gelatinase-associated lipocalin: p = 0.045, midkine: p = 0.072). Conclusion: COMT genotype may associate with different patterns of renal functional changes and tubular stress biomarker release response after open heart surgery.

Original language	English
Pages (from-to)	1227-1238
Number of pages	12
Journal	Biomarkers in Medicine
Volume	8
Issue number	10
DOIs	https://doi.org/10.2217/bmm.14.85
Publication status	Published - Dec 2014
Externally published	Yes

Keywords

acute kidney injury
COMT
midkine
neutrophil gelatinase-associated lipocalin
NGAL
open heart surgery
rs4680
tubular stress
Val158Met SNP

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10.2217/bmm.14.85

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Albert, C., Kube, J., Haase-Fielitz, A., Dittrich, A., Schanze, D., Zenker, M., Kuppe, H., Hetzer, R., Bellomo, R., Mertens, P. R., & Haase, M. (2014). Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery. Biomarkers in Medicine, 8(10), 1227-1238. https://doi.org/10.2217/bmm.14.85

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title = "Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery",

abstract = "Aim: To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery. Patients & methods: We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, neutrophil gelatinase-associated lipocalin and midkine. We analyzed the association between such polymorphisms and these kidney-related variables. Results: Nonsignificantly more COMT LL patients developed RIFLE-AKI compared with non-LL patients (p = 0.11). Compared with HL and HH patients, LL patients who developed AKI had lower increases in serum creatinine. COMT LL patients had less pronounced release of tubular stress biomarkers (neutrophil gelatinase-associated lipocalin: p = 0.045, midkine: p = 0.072). Conclusion: COMT genotype may associate with different patterns of renal functional changes and tubular stress biomarker release response after open heart surgery.",

keywords = "acute kidney injury, COMT, midkine, neutrophil gelatinase-associated lipocalin, NGAL, open heart surgery, rs4680, tubular stress, Val158Met SNP",

author = "Christian Albert and Johanna Kube and Anja Haase-Fielitz and Annemarie Dittrich and Denny Schanze and Martin Zenker and Hermann Kuppe and Roland Hetzer and Rinaldo Bellomo and Mertens, {Peter R.} and Michael Haase",

year = "2014",

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doi = "10.2217/bmm.14.85",

language = "English",

volume = "8",

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Albert, C, Kube, J, Haase-Fielitz, A, Dittrich, A, Schanze, D, Zenker, M, Kuppe, H, Hetzer, R, Bellomo, R, Mertens, PR & Haase, M 2014, 'Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery', Biomarkers in Medicine, vol. 8, no. 10, pp. 1227-1238. https://doi.org/10.2217/bmm.14.85

TY - JOUR

T1 - Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery

AU - Albert, Christian

AU - Kube, Johanna

AU - Haase-Fielitz, Anja

AU - Dittrich, Annemarie

AU - Schanze, Denny

AU - Zenker, Martin

AU - Kuppe, Hermann

AU - Hetzer, Roland

AU - Bellomo, Rinaldo

AU - Mertens, Peter R.

AU - Haase, Michael

PY - 2014/12

Y1 - 2014/12

N2 - Aim: To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery. Patients & methods: We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, neutrophil gelatinase-associated lipocalin and midkine. We analyzed the association between such polymorphisms and these kidney-related variables. Results: Nonsignificantly more COMT LL patients developed RIFLE-AKI compared with non-LL patients (p = 0.11). Compared with HL and HH patients, LL patients who developed AKI had lower increases in serum creatinine. COMT LL patients had less pronounced release of tubular stress biomarkers (neutrophil gelatinase-associated lipocalin: p = 0.045, midkine: p = 0.072). Conclusion: COMT genotype may associate with different patterns of renal functional changes and tubular stress biomarker release response after open heart surgery.

AB - Aim: To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery. Patients & methods: We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, neutrophil gelatinase-associated lipocalin and midkine. We analyzed the association between such polymorphisms and these kidney-related variables. Results: Nonsignificantly more COMT LL patients developed RIFLE-AKI compared with non-LL patients (p = 0.11). Compared with HL and HH patients, LL patients who developed AKI had lower increases in serum creatinine. COMT LL patients had less pronounced release of tubular stress biomarkers (neutrophil gelatinase-associated lipocalin: p = 0.045, midkine: p = 0.072). Conclusion: COMT genotype may associate with different patterns of renal functional changes and tubular stress biomarker release response after open heart surgery.

KW - acute kidney injury

KW - COMT

KW - midkine

KW - neutrophil gelatinase-associated lipocalin

KW - NGAL

KW - open heart surgery

KW - rs4680

KW - tubular stress

KW - Val158Met SNP

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U2 - 10.2217/bmm.14.85

DO - 10.2217/bmm.14.85

M3 - Article

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AN - SCOPUS:84919792720

SN - 1752-0363

VL - 8

SP - 1227

EP - 1238

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 10

ER -

Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery

Abstract

Keywords

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