Pilot study evaluating the role of cardiac magnetic resonance imaging in monitoring adjuvant trastuzumab therapy for breast cancer

Claire Lawley, Camilla Wainwright, Eva Segelov, Jodi Lynch, Jane Beith, Jane Mccrohon

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Aim: To explore the incidence of subclinical cardiotoxicity in women treated with adjuvant trastuzumab in the early breast cancer setting using cardiac magnetic resonance imaging (cMRI). Methods: The cardiac function and myocardial tissue characteristics of 25 women who had completed adjuvant trastuzumab therapy greater than 6months previously was evaluated using MRI and comparing this with symptoms and routine echocardiography. Results: Evidence of myocardial tissue damage was seen in two women in the absence of functional change or previous cardiac symptoms. Conclusion: Tissue characterization using cMRI may provide a useful tool in defining trastuzumab induced cardiotoxicity.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalAsia-Pacific Journal of Clinical Oncology
Volume8
Issue number1
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Breast cancer
  • Cardiac magnetic resonance imaging
  • Cardiotoxicity
  • Trastuzumab

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