Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: impact of exercise training

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Abstract

Pigment epithelium-derived factor (PEDF) is upregulated in obese rodents and is involved in the development of insulin resistance (IR). We aim to explore the relationships between PEDF, adiposity, insulin sensitivity and cardiovascular risk factors in obese women with Polycystic Ovary Syndrome (PCOS) and weight-matched controls and to examine the impact of endurance exercise training on PEDF.This prospective cohort intervention study was based at a tertiary medical centre. 20 obese PCOS women and 14 non-PCOS weight-matched women were studied at baseline. PEDF, cardiometabolic markers, detailed body composition and euglycaemic hyperinsulinaemic clamps were performed and measures were repeated in 10 PCOS and 8 non-PCOS women following 12 weeks of intensified aerobic exercise.Mean GIR was 31.7 lower (p=0.02) in PCOS compared to controls [175.3+/-96.3 and 257.2+/-64.3 mg.m(-2).min(-1)] at baseline, yet both PEDF and BMI were similar between groups. PEDF negatively correlated to GIR [r=-0.41, p=0.03] and HDL (r=-0.46, p=0.01) and positively to cardiovascular risk factors [systolic (r=0.41, p=0.02) and diastolic blood pressure (r=0.47, p=0.01) and triglycerides (r=0.49, p=0.004). The correlation with GIR was not significant after adjusting for fat mass (p=0.07). Exercise training maintained BMI and increased GIR in both groups, however, plasma PEDF was unchanged.In summary, PEDF is not elevated in PCOS, is not associated with IR when adjusted for fat mass and is not reduced by endurance exercise training despite improved insulin sensitivity. PEDF was associated with cardiovascular risk factors, suggesting PEDF may be a marker of cardiovascular risk status.
Original languageEnglish
Pages (from-to)2390 - 2396
Number of pages7
JournalObesity
Volume20
Issue number12
DOIs
Publication statusPublished - 2012

Cite this

@article{8e867a95809c4906955dac6e746016fb,
title = "Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: impact of exercise training",
abstract = "Pigment epithelium-derived factor (PEDF) is upregulated in obese rodents and is involved in the development of insulin resistance (IR). We aim to explore the relationships between PEDF, adiposity, insulin sensitivity and cardiovascular risk factors in obese women with Polycystic Ovary Syndrome (PCOS) and weight-matched controls and to examine the impact of endurance exercise training on PEDF.This prospective cohort intervention study was based at a tertiary medical centre. 20 obese PCOS women and 14 non-PCOS weight-matched women were studied at baseline. PEDF, cardiometabolic markers, detailed body composition and euglycaemic hyperinsulinaemic clamps were performed and measures were repeated in 10 PCOS and 8 non-PCOS women following 12 weeks of intensified aerobic exercise.Mean GIR was 31.7 lower (p=0.02) in PCOS compared to controls [175.3+/-96.3 and 257.2+/-64.3 mg.m(-2).min(-1)] at baseline, yet both PEDF and BMI were similar between groups. PEDF negatively correlated to GIR [r=-0.41, p=0.03] and HDL (r=-0.46, p=0.01) and positively to cardiovascular risk factors [systolic (r=0.41, p=0.02) and diastolic blood pressure (r=0.47, p=0.01) and triglycerides (r=0.49, p=0.004). The correlation with GIR was not significant after adjusting for fat mass (p=0.07). Exercise training maintained BMI and increased GIR in both groups, however, plasma PEDF was unchanged.In summary, PEDF is not elevated in PCOS, is not associated with IR when adjusted for fat mass and is not reduced by endurance exercise training despite improved insulin sensitivity. PEDF was associated with cardiovascular risk factors, suggesting PEDF may be a marker of cardiovascular risk status.",
author = "Joham, {Anju E} and Teede, {Helena J} and Hutchison, {Samantha Kate} and Stepto, {Nigel K} and Harrison, {Cheryce L} and Strauss, {Boyd Josef Gimnicher} and Eldho Paul and Watt, {Matthew J}",
year = "2012",
doi = "10.1038/oby.2012.135",
language = "English",
volume = "20",
pages = "2390 -- 2396",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
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}

Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: impact of exercise training. / Joham, Anju E; Teede, Helena J; Hutchison, Samantha Kate; Stepto, Nigel K; Harrison, Cheryce L; Strauss, Boyd Josef Gimnicher; Paul, Eldho; Watt, Matthew J.

In: Obesity, Vol. 20, No. 12, 2012, p. 2390 - 2396.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Pigment epithelium-derived factor, insulin sensitivity, and adiposity in polycystic ovary syndrome: impact of exercise training

AU - Joham, Anju E

AU - Teede, Helena J

AU - Hutchison, Samantha Kate

AU - Stepto, Nigel K

AU - Harrison, Cheryce L

AU - Strauss, Boyd Josef Gimnicher

AU - Paul, Eldho

AU - Watt, Matthew J

PY - 2012

Y1 - 2012

N2 - Pigment epithelium-derived factor (PEDF) is upregulated in obese rodents and is involved in the development of insulin resistance (IR). We aim to explore the relationships between PEDF, adiposity, insulin sensitivity and cardiovascular risk factors in obese women with Polycystic Ovary Syndrome (PCOS) and weight-matched controls and to examine the impact of endurance exercise training on PEDF.This prospective cohort intervention study was based at a tertiary medical centre. 20 obese PCOS women and 14 non-PCOS weight-matched women were studied at baseline. PEDF, cardiometabolic markers, detailed body composition and euglycaemic hyperinsulinaemic clamps were performed and measures were repeated in 10 PCOS and 8 non-PCOS women following 12 weeks of intensified aerobic exercise.Mean GIR was 31.7 lower (p=0.02) in PCOS compared to controls [175.3+/-96.3 and 257.2+/-64.3 mg.m(-2).min(-1)] at baseline, yet both PEDF and BMI were similar between groups. PEDF negatively correlated to GIR [r=-0.41, p=0.03] and HDL (r=-0.46, p=0.01) and positively to cardiovascular risk factors [systolic (r=0.41, p=0.02) and diastolic blood pressure (r=0.47, p=0.01) and triglycerides (r=0.49, p=0.004). The correlation with GIR was not significant after adjusting for fat mass (p=0.07). Exercise training maintained BMI and increased GIR in both groups, however, plasma PEDF was unchanged.In summary, PEDF is not elevated in PCOS, is not associated with IR when adjusted for fat mass and is not reduced by endurance exercise training despite improved insulin sensitivity. PEDF was associated with cardiovascular risk factors, suggesting PEDF may be a marker of cardiovascular risk status.

AB - Pigment epithelium-derived factor (PEDF) is upregulated in obese rodents and is involved in the development of insulin resistance (IR). We aim to explore the relationships between PEDF, adiposity, insulin sensitivity and cardiovascular risk factors in obese women with Polycystic Ovary Syndrome (PCOS) and weight-matched controls and to examine the impact of endurance exercise training on PEDF.This prospective cohort intervention study was based at a tertiary medical centre. 20 obese PCOS women and 14 non-PCOS weight-matched women were studied at baseline. PEDF, cardiometabolic markers, detailed body composition and euglycaemic hyperinsulinaemic clamps were performed and measures were repeated in 10 PCOS and 8 non-PCOS women following 12 weeks of intensified aerobic exercise.Mean GIR was 31.7 lower (p=0.02) in PCOS compared to controls [175.3+/-96.3 and 257.2+/-64.3 mg.m(-2).min(-1)] at baseline, yet both PEDF and BMI were similar between groups. PEDF negatively correlated to GIR [r=-0.41, p=0.03] and HDL (r=-0.46, p=0.01) and positively to cardiovascular risk factors [systolic (r=0.41, p=0.02) and diastolic blood pressure (r=0.47, p=0.01) and triglycerides (r=0.49, p=0.004). The correlation with GIR was not significant after adjusting for fat mass (p=0.07). Exercise training maintained BMI and increased GIR in both groups, however, plasma PEDF was unchanged.In summary, PEDF is not elevated in PCOS, is not associated with IR when adjusted for fat mass and is not reduced by endurance exercise training despite improved insulin sensitivity. PEDF was associated with cardiovascular risk factors, suggesting PEDF may be a marker of cardiovascular risk status.

UR - http://onlinelibrary.wiley.com/doi/10.1038/oby.2012.135/pdf

U2 - 10.1038/oby.2012.135

DO - 10.1038/oby.2012.135

M3 - Article

VL - 20

SP - 2390

EP - 2396

JO - Obesity

JF - Obesity

SN - 1930-7381

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