PIC-king apart PRC1-mediated repression

Evan Healy; Adrian P. Bracken

doi:10.1016/j.tig.2024.10.013

PIC-king apart PRC1-mediated repression

Evan Healy, Adrian P. Bracken

Research output: Contribution to journal › Article › Other › peer-review

Abstract

Polycomb repressive complex 1 (PRC1) is an essential repressor of lineage-specific genes central to the establishment and preservation of cellular identity. Recent findings by Szczurek et al. show that the noncanonical form of PRC1 (ncPRC1), which mediates H2AK119ub1, promotes a deep OFF state at promoters by blocking transcription initiation.

Original language	English
Pages (from-to)	4-5
Number of pages	2
Journal	Trends in Genetics
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.tig.2024.10.013
Publication status	Published - Jan 2025

Keywords

gene repression
live-cell imaging
ncPRC1
Polycomb
transcription

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10.1016/j.tig.2024.10.013Licence: CC BY-NC-ND

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abstract = "Polycomb repressive complex 1 (PRC1) is an essential repressor of lineage-specific genes central to the establishment and preservation of cellular identity. Recent findings by Szczurek et al. show that the noncanonical form of PRC1 (ncPRC1), which mediates H2AK119ub1, promotes a deep OFF state at promoters by blocking transcription initiation.",

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KW - Polycomb

KW - transcription

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PIC-king apart PRC1-mediated repression

Abstract

Keywords

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