TY - JOUR
T1 - Phytogenic polyphenols as glycogen phosphorylase inhibitors
T2 - The potential of triterpenes and flavonoids for glycaemic control in type 2 diabetes
AU - Stravodimos, George A.
AU - Chetter, Ben A.
AU - Kyriakis, Efthimios
AU - Kantsadi, Anastassia L.
AU - Chatzileontiadou, Demetra S.M.
AU - Skamnaki, Vassiliki T.
AU - Kato, Atsushi
AU - Hayes, Joseph M.
AU - Leonidas, Demetres D.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Glycogen phosphorylase (GP) is a validated pharmaceutical target for the development of antihyperglycaemic agents. Phytogenic polyphenols, mainly flavonoids and pentacyclic triterpenes, have been found to be potent inhibitors of GP. These compounds have both pharmaceutical and nutraceutical potential for glycemic control in diabetes type 2. This review focuses mainly on the most successful (potent) of these compounds discovered to date. The protein-ligand interactions that form the structural basis of their potencies are discussed, highlighting the potential for exploitation of their scaffolds in the future design of new GP inhibitors.
AB - Glycogen phosphorylase (GP) is a validated pharmaceutical target for the development of antihyperglycaemic agents. Phytogenic polyphenols, mainly flavonoids and pentacyclic triterpenes, have been found to be potent inhibitors of GP. These compounds have both pharmaceutical and nutraceutical potential for glycemic control in diabetes type 2. This review focuses mainly on the most successful (potent) of these compounds discovered to date. The protein-ligand interactions that form the structural basis of their potencies are discussed, highlighting the potential for exploitation of their scaffolds in the future design of new GP inhibitors.
KW - Alpha-glucosidases
KW - Antioxidants
KW - Diabetes
KW - Flavonoids
KW - Glycogen phosphorylase
KW - Pentacyclic triterpenes
UR - http://www.scopus.com/inward/record.url?scp=85016162210&partnerID=8YFLogxK
U2 - 10.2174/0929867324666161118122534
DO - 10.2174/0929867324666161118122534
M3 - Review Article
C2 - 27855623
AN - SCOPUS:85016162210
SN - 0929-8673
VL - 24
SP - 384
EP - 403
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 4
ER -
