Phytochemical profiling, antioxidant, enzyme inhibition and cytotoxic potential of Bougainvillea glabra flowers

Hammad Saleem, Thet Thet Htar, Rakesh Naidu, Gokhan Zengin, Irshad Ahmad, Nafees Ahemad

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    2 Citations (Scopus)

    Abstract

    In this study, phytochemical composition, antioxidant, enzyme inhibition and cytotoxic activities of methanol and dichloromethane (DCM) extracts of Bougainvillea glabra (B. glabra) flowers were investigated. Methanol extract was found to have higher total bioactive contents and UHPLC-MS analysis of methanol extract revealed the presence of well-known phenolic and flavonoid compounds. Antioxidant activities were performed by radical scavenging (DPPH and ABTS), reducing power (FRAP and CUPRAC), phosphomolybdenum (TAC) and metal chelating assays. From our result, we observed that methanol extract had many antioxidant compounds. The DCM extract exhibited higher cholinesterases and α-glucosidase enzyme inhibition, while methanol extract showed significant urease inhibition. Both extracts exhibited strong to moderate cytotoxicity against MCF-7, MDA-MB-231, CaSki, DU-145 and SW-480 cancer cells with IC50 values ranging from 88.49 to 304.7 µg/mL. The findings showed the B. glabra to possess considerable antioxidant, enzyme inhibition and cytotoxic potentials and therefore has potential to discover novel bioactive molecules.

    Original languageEnglish
    Pages (from-to)2602-2606
    Number of pages5
    JournalNatural Product Research
    Volume34
    Issue number18
    DOIs
    Publication statusPublished - 16 Sep 2020

    Keywords

    • Antioxidant
    • Bougainvillea glabra
    • Cytotoxicity
    • Enzyme inhibition
    • Phytochemical

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