Physiological effects of reducing and breaking up sitting time

The reader will gain an overview of the physiological implications of sedentary behavior with a specific focus on the emergence of recent human experimental studies examining potential causal relationships and effective solutions for mitigating the adverse health consequences of prolonged sitting. By the end of this chapter, the reader should be able to do the following: Better understand the scientific, public health, and clinical benefits of reducing sitting time; Identify key aspects of study design, control conditions, and methodologies required for human experimental studies on the physiological implications of reducing sitting time; Describe recent human experimental studies on the physiological implications of reducing and breaking up sitting time; Identify directions for future research on the potential biological mechanisms that underlie sedentary behavior and health.