Physiological effects of androgens on human vascular endothelial and smooth muscle cells in culture

Lina Nheu, Lester Nazareth, Guo-Hing Xu, Fu-Ying Xiao, Rui-Zhi Luo, Paul Alter Komesaroff, Shanhong Ling

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Abstract

We examine the effect of androgens on human vascular cells in culture. ? Dehydroepiandrosterone protects endothelial cells (EC) from superoxide injury. ? Testosterone enhances ERK activation and growth in EC and smooth muscle cells (SMC). ? The testosterone actions are independent on the classical androgen receptor (AR). ? Dihydrotestosterone inhibits EC but stimulates SMC growth via AR mediation
Original languageEnglish
Pages (from-to)1590 - 1596
Number of pages7
JournalSteroids
Volume76
Issue number14
DOIs
Publication statusPublished - 2011

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