Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 693 - 702 |
| Number of pages | 10 |
| Journal | Microsurgery |
| Volume | 15 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1994 |
Cite this
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Physiological and pathophysiological roles of nitric oxide. / Stewart, Alastair G; Phan, Long H; Grigoriadis, George.
In: Microsurgery, Vol. 15, No. 10, 1994, p. 693 - 702.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Physiological and pathophysiological roles of nitric oxide
AU - Stewart, Alastair G
AU - Phan, Long H
AU - Grigoriadis, George
PY - 1994
Y1 - 1994
N2 - Nitric oxide (NO), identified as the biochemical messenger of endothelial- dependent relaxation, is of obvious chemical simplicity, but the range and complexity of its biological actions are only now emerging. NO is an important determinant of vascular resistance, it reduces thrombogenicity of the vascular endothelium, contributes to non-specific, host-defence mechanisms, and is a neurotransmitter in the peripheral and central nervous systems. In addition to these physiological roles, there is now convincing evidence that excessive, prolonged production of NO contributes to tissue damage in septicemia, ischemia/reperfusion injury, and other inflammatory conditions.
AB - Nitric oxide (NO), identified as the biochemical messenger of endothelial- dependent relaxation, is of obvious chemical simplicity, but the range and complexity of its biological actions are only now emerging. NO is an important determinant of vascular resistance, it reduces thrombogenicity of the vascular endothelium, contributes to non-specific, host-defence mechanisms, and is a neurotransmitter in the peripheral and central nervous systems. In addition to these physiological roles, there is now convincing evidence that excessive, prolonged production of NO contributes to tissue damage in septicemia, ischemia/reperfusion injury, and other inflammatory conditions.
UR - http://onlinelibrary.wiley.com.ezproxy.lib.monash.edu.au/doi/10.1002/micr.1920151006/pdf
U2 - 10.1002/micr.1920151006
DO - 10.1002/micr.1920151006
M3 - Article
VL - 15
SP - 693
EP - 702
JO - Microsurgery
JF - Microsurgery
SN - 0738-1085
IS - 10
ER -