Physicochemical properties, in vitro antioxidant activities and inhibitory potential against α-glucosidase of polysaccharides from ampelopsis grossedentata leaves and stems

Yuefei Wang; Xiaoying Bian; Jinhyouch Park; Le Ying; Lisheng Qian; Ping Xu

doi:10.3390/molecules16097762

Physicochemical properties, in vitro antioxidant activities and inhibitory potential against α-glucosidase of polysaccharides from ampelopsis grossedentata leaves and stems

Yuefei Wang, Xiaoying Bian, Jinhyouch Park, Le Ying, Lisheng Qian, Ping Xu

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Abstract

In the present study, polysaccharides named ALPS and ASPS were isolated from Ampelopsis grossedentata leaves and stems, respectively. Physicochemical properties, in vitro antioxidant activities and the inhibitory effects on α-glucosidase of ALPS and ASPS were investigated. It was found that both ALPS and ASPS were acid protein-bound heteropolysaccharides, although with considerably different chemical composition and molecular weight distribution. Meanwhile, in comparison with ALPS, ASPS exhibited stronger antioxidant activity and inhibitory potential against α-glucosidase according to the in vitro evaluation. Moreover, our results suggested that protein and uronic acid might, at least partly, contribute positively to the biological behavior of ALPS and ASPS.

Original language	English
Pages (from-to)	7762-7772
Number of pages	11
Journal	Molecules
Volume	16
Issue number	9
DOIs	https://doi.org/10.3390/molecules16097762
Publication status	Published - Sep 2011
Externally published	Yes

Keywords

α-glucosidase inhibition
Ampelopsis grossedentata
Antioxidant activities
Physicochemical properties
Polysaccharides

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10.3390/molecules16097762

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title = "Physicochemical properties, in vitro antioxidant activities and inhibitory potential against α-glucosidase of polysaccharides from ampelopsis grossedentata leaves and stems",

abstract = "In the present study, polysaccharides named ALPS and ASPS were isolated from Ampelopsis grossedentata leaves and stems, respectively. Physicochemical properties, in vitro antioxidant activities and the inhibitory effects on α-glucosidase of ALPS and ASPS were investigated. It was found that both ALPS and ASPS were acid protein-bound heteropolysaccharides, although with considerably different chemical composition and molecular weight distribution. Meanwhile, in comparison with ALPS, ASPS exhibited stronger antioxidant activity and inhibitory potential against α-glucosidase according to the in vitro evaluation. Moreover, our results suggested that protein and uronic acid might, at least partly, contribute positively to the biological behavior of ALPS and ASPS.",

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T1 - Physicochemical properties, in vitro antioxidant activities and inhibitory potential against α-glucosidase of polysaccharides from ampelopsis grossedentata leaves and stems

AU - Wang, Yuefei

AU - Bian, Xiaoying

AU - Park, Jinhyouch

AU - Ying, Le

AU - Qian, Lisheng

AU - Xu, Ping

PY - 2011/9

Y1 - 2011/9

N2 - In the present study, polysaccharides named ALPS and ASPS were isolated from Ampelopsis grossedentata leaves and stems, respectively. Physicochemical properties, in vitro antioxidant activities and the inhibitory effects on α-glucosidase of ALPS and ASPS were investigated. It was found that both ALPS and ASPS were acid protein-bound heteropolysaccharides, although with considerably different chemical composition and molecular weight distribution. Meanwhile, in comparison with ALPS, ASPS exhibited stronger antioxidant activity and inhibitory potential against α-glucosidase according to the in vitro evaluation. Moreover, our results suggested that protein and uronic acid might, at least partly, contribute positively to the biological behavior of ALPS and ASPS.

AB - In the present study, polysaccharides named ALPS and ASPS were isolated from Ampelopsis grossedentata leaves and stems, respectively. Physicochemical properties, in vitro antioxidant activities and the inhibitory effects on α-glucosidase of ALPS and ASPS were investigated. It was found that both ALPS and ASPS were acid protein-bound heteropolysaccharides, although with considerably different chemical composition and molecular weight distribution. Meanwhile, in comparison with ALPS, ASPS exhibited stronger antioxidant activity and inhibitory potential against α-glucosidase according to the in vitro evaluation. Moreover, our results suggested that protein and uronic acid might, at least partly, contribute positively to the biological behavior of ALPS and ASPS.

KW - α-glucosidase inhibition

KW - Ampelopsis grossedentata

KW - Antioxidant activities

KW - Physicochemical properties

KW - Polysaccharides

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DO - 10.3390/molecules16097762

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Physicochemical properties, in vitro antioxidant activities and inhibitory potential against α-glucosidase of polysaccharides from ampelopsis grossedentata leaves and stems

Abstract

Keywords

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