Physical Principles of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MRI

Mark S. Shiroishi; Jerrold L. Boxerman; C. Chad Quarles; Daniel S.R. Stahl; Saulo Lacerda; Naira Muradyan; Timothy P.L. Roberts; Meng Law

doi:10.1007/978-3-031-10909-6_2

Physical Principles of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MRI

Mark S. Shiroishi, Jerrold L. Boxerman, C. Chad Quarles, Daniel S.R. Stahl, Saulo Lacerda, Naira Muradyan, Timothy P.L. Roberts, Meng Law

Electrical and Computer Systems Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

2 Citations (Scopus)

Abstract

The use of dynamic contrast-agent-enhanced magnetic resonance imaging (MRI) can provide insight into hemodynamic processes not detectable using conventional contrast-enhanced magnetic resonance (MR) techniques. This additional data may allow refinement of differential diagnoses based on microvascular physiology. The dominant dynamic gadolinium-based contrast agent (GBCA) injection MRI techniques currently utilized in brain imaging are: (1) T1-weighted dynamic contrast-enhanced (DCE) MRI, and (2) T2/T2*-weighted dynamic susceptibility contrast (DSC) MRI. DSC-MRI is much more commonly used for clinical perfusion imaging of the brain, especially for the evaluation of stroke and tumor. On the other hand, DCE-MRI is the dominant method of dynamic contrast-enhanced MRI outside of the brain. In both DCE-MRI and DSC-MRI, dynamic images are acquired before, during, and after the administration of an exogenous GBCA. This chapter will provide an overview of the general physical principles of these techniques.

Original language	English
Title of host publication	Functional Neuroradiology
Subtitle of host publication	Principles and Clinical Applications, Second Edition
Editors	Scott H. Faro, Feroze B. Mohamed
Place of Publication	Cham Switzerland
Publisher	Springer
Chapter	2
Pages	15-34
Number of pages	20
Edition	2nd
ISBN (Electronic)	9783031109096
ISBN (Print)	9783031109089
DOIs	https://doi.org/10.1007/978-3-031-10909-6_2
Publication status	Published - 2023

Keywords

Dynamic contrast-enhanced MRI
Dynamic susceptibility contrast MRI
Magnetic resonance imaging

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10.1007/978-3-031-10909-6_2

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Shiroishi, M. S., Boxerman, J. L., Quarles, C. C., Stahl, D. S. R., Lacerda, S., Muradyan, N., Roberts, T. P. L., & Law, M. (2023). Physical Principles of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MRI. In S. H. Faro, & F. B. Mohamed (Eds.), Functional Neuroradiology: Principles and Clinical Applications, Second Edition (2nd ed., pp. 15-34). Springer. https://doi.org/10.1007/978-3-031-10909-6_2

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abstract = "The use of dynamic contrast-agent-enhanced magnetic resonance imaging (MRI) can provide insight into hemodynamic processes not detectable using conventional contrast-enhanced magnetic resonance (MR) techniques. This additional data may allow refinement of differential diagnoses based on microvascular physiology. The dominant dynamic gadolinium-based contrast agent (GBCA) injection MRI techniques currently utilized in brain imaging are: (1) T1-weighted dynamic contrast-enhanced (DCE) MRI, and (2) T2/T2*-weighted dynamic susceptibility contrast (DSC) MRI. DSC-MRI is much more commonly used for clinical perfusion imaging of the brain, especially for the evaluation of stroke and tumor. On the other hand, DCE-MRI is the dominant method of dynamic contrast-enhanced MRI outside of the brain. In both DCE-MRI and DSC-MRI, dynamic images are acquired before, during, and after the administration of an exogenous GBCA. This chapter will provide an overview of the general physical principles of these techniques.",

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Shiroishi, MS, Boxerman, JL, Quarles, CC, Stahl, DSR, Lacerda, S, Muradyan, N, Roberts, TPL & Law, M 2023, Physical Principles of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MRI. in S H. Faro & F B. Mohamed (eds), Functional Neuroradiology: Principles and Clinical Applications, Second Edition. 2nd edn, Springer, Cham Switzerland, pp. 15-34. https://doi.org/10.1007/978-3-031-10909-6_2

Physical Principles of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MRI. / Shiroishi, Mark S.; Boxerman, Jerrold L.; Quarles, C. Chad et al.
Functional Neuroradiology: Principles and Clinical Applications, Second Edition. ed. / Scott H. Faro; Feroze B. Mohamed. 2nd. ed. Cham Switzerland: Springer, 2023. p. 15-34.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

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AU - Stahl, Daniel S.R.

AU - Lacerda, Saulo

AU - Muradyan, Naira

AU - Roberts, Timothy P.L.

AU - Law, Meng

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

PY - 2023

Y1 - 2023

N2 - The use of dynamic contrast-agent-enhanced magnetic resonance imaging (MRI) can provide insight into hemodynamic processes not detectable using conventional contrast-enhanced magnetic resonance (MR) techniques. This additional data may allow refinement of differential diagnoses based on microvascular physiology. The dominant dynamic gadolinium-based contrast agent (GBCA) injection MRI techniques currently utilized in brain imaging are: (1) T1-weighted dynamic contrast-enhanced (DCE) MRI, and (2) T2/T2*-weighted dynamic susceptibility contrast (DSC) MRI. DSC-MRI is much more commonly used for clinical perfusion imaging of the brain, especially for the evaluation of stroke and tumor. On the other hand, DCE-MRI is the dominant method of dynamic contrast-enhanced MRI outside of the brain. In both DCE-MRI and DSC-MRI, dynamic images are acquired before, during, and after the administration of an exogenous GBCA. This chapter will provide an overview of the general physical principles of these techniques.

AB - The use of dynamic contrast-agent-enhanced magnetic resonance imaging (MRI) can provide insight into hemodynamic processes not detectable using conventional contrast-enhanced magnetic resonance (MR) techniques. This additional data may allow refinement of differential diagnoses based on microvascular physiology. The dominant dynamic gadolinium-based contrast agent (GBCA) injection MRI techniques currently utilized in brain imaging are: (1) T1-weighted dynamic contrast-enhanced (DCE) MRI, and (2) T2/T2*-weighted dynamic susceptibility contrast (DSC) MRI. DSC-MRI is much more commonly used for clinical perfusion imaging of the brain, especially for the evaluation of stroke and tumor. On the other hand, DCE-MRI is the dominant method of dynamic contrast-enhanced MRI outside of the brain. In both DCE-MRI and DSC-MRI, dynamic images are acquired before, during, and after the administration of an exogenous GBCA. This chapter will provide an overview of the general physical principles of these techniques.

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Shiroishi MS, Boxerman JL, Quarles CC, Stahl DSR, Lacerda S, Muradyan N et al. Physical Principles of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MRI. In H. Faro S, B. Mohamed F, editors, Functional Neuroradiology: Principles and Clinical Applications, Second Edition. 2nd ed. Cham Switzerland: Springer. 2023. p. 15-34 doi: 10.1007/978-3-031-10909-6_2

Physical Principles of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MRI

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