TY - JOUR
T1 - Physical activity attenuated the association of air pollutants with telomere length in rural Chinese adults
AU - Li, Ruiying
AU - Li, Shanshan
AU - Pan, Mingming
AU - Chen, Hao
AU - Liu, Xiaotian
AU - Chen, Gongbo
AU - Chen, Ruoling
AU - Mao, Zhenxing
AU - Huo, Wenqian
AU - Wang, Xian
AU - Yu, Songcheng
AU - Duan, Yanying
AU - Guo, Yuming
AU - Hou, Jian
AU - Wang, Chongjian
PY - 2021/3/10
Y1 - 2021/3/10
N2 - Background: Exposure to air pollutants (nitrogen dioxide (NO2) and particulate matters (PMs)) or physical inactivity is linked to telomere length (TL) shortening. However, there is a lack of research on combined effects of either NO2 or PMs and physical activity (PA) on TL. This study aimed to explore the joint associations of air pollutants (NO2 or PMs) and PA with relative TL in rural Chinese adults. Methods: This study was conducted among 2704 participants aged 18–79 years in rural China. Concentrations of NO2 and PMs (PM with an aerodynamics diameter ≤ 1.0 μm (PM1), ≤2.5 μm (PM2.5) or ≤10 μm (PM10)) were estimated using random forest models incorporated with satellites data, meteorological data, and land use information. Relative TL of each participant was measured by a quantitative real-time polymerase chain reaction. Linear regression models were applied to examine the independent associations between PA, NO2 or PMs and relative TL. Interaction plots were used to depict the altered associations between NO2, PM1, PM2.5, or PM10 and relative TL along with increasing PA levels. Results: Each 1 μg/m3 increment in NO2, PM1, PM2.5, or PM10 was associated with a 0.038 (95% confidence intervals (CI): −0.044, −0.033), 0.036 (95% CI: −0.041, −0.031), 0.052 (95% CI: −0.059, −0.045), or 0.022 (95% CI: −0.025, −0.019) decrease in relative TL among all participants; similar findings were observed among normal glucose tolerance or impaired fasting glucose (IFG) participants as well as type 2 diabetes mellitus (T2DM) patients. PA at certain levels counteracted the association of air pollutants (NO2, PM1, PM2.5, and PM10) with relative TL among IFG participants or T2DM patients. Conclusions: Long-term exposure to NO2 and PMs was associated with relative TL shortening and these effects may be counteracted by PA at certain levels in IFG participants or T2DM patients.
AB - Background: Exposure to air pollutants (nitrogen dioxide (NO2) and particulate matters (PMs)) or physical inactivity is linked to telomere length (TL) shortening. However, there is a lack of research on combined effects of either NO2 or PMs and physical activity (PA) on TL. This study aimed to explore the joint associations of air pollutants (NO2 or PMs) and PA with relative TL in rural Chinese adults. Methods: This study was conducted among 2704 participants aged 18–79 years in rural China. Concentrations of NO2 and PMs (PM with an aerodynamics diameter ≤ 1.0 μm (PM1), ≤2.5 μm (PM2.5) or ≤10 μm (PM10)) were estimated using random forest models incorporated with satellites data, meteorological data, and land use information. Relative TL of each participant was measured by a quantitative real-time polymerase chain reaction. Linear regression models were applied to examine the independent associations between PA, NO2 or PMs and relative TL. Interaction plots were used to depict the altered associations between NO2, PM1, PM2.5, or PM10 and relative TL along with increasing PA levels. Results: Each 1 μg/m3 increment in NO2, PM1, PM2.5, or PM10 was associated with a 0.038 (95% confidence intervals (CI): −0.044, −0.033), 0.036 (95% CI: −0.041, −0.031), 0.052 (95% CI: −0.059, −0.045), or 0.022 (95% CI: −0.025, −0.019) decrease in relative TL among all participants; similar findings were observed among normal glucose tolerance or impaired fasting glucose (IFG) participants as well as type 2 diabetes mellitus (T2DM) patients. PA at certain levels counteracted the association of air pollutants (NO2, PM1, PM2.5, and PM10) with relative TL among IFG participants or T2DM patients. Conclusions: Long-term exposure to NO2 and PMs was associated with relative TL shortening and these effects may be counteracted by PA at certain levels in IFG participants or T2DM patients.
KW - Nitrogen dioxide
KW - Particulate matter
KW - Physical activity
KW - Relative telomere length
KW - Rural population
UR - http://www.scopus.com/inward/record.url?scp=85096446774&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2020.143491
DO - 10.1016/j.scitotenv.2020.143491
M3 - Article
C2 - 33218817
AN - SCOPUS:85096446774
VL - 759
JO - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
M1 - 143491
ER -