Physical Activity after Stroke Is Associated with Increased Interhemispheric Connectivity of the Dorsal Attention Network

Michele Veldsman, Leonid Churilov, Emilio Werden, Qi Li, Toby B Cumming, Amy Brodtmann

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19 Citations (Scopus)

Abstract

Background. Attention is frequently impaired after stroke, and its impairment is associated with poor quality of life. Physical activity benefits attention in healthy populations and has also been associated with recovery after brain injury. Objective. We investigated the relationship between objectively measured daily physical activity, attention network connectivity, and attention task performance after stroke. We hypothesized that increased daily physical activity would be associated with improved attention network function. Methods. Stroke patients (n = 62; mean age = 67 years, SD = 12.6 years) and healthy controls (n = 27; mean age = 68 years, SD = 6 years) underwent cognitive testing and 7 minutes of functional magnetic resonance imaging in the resting-state. Patients were tested 3 months after ischemic stroke. Physical activity was monitored with an electronic armband worn for 7 days. Dorsal and ventral attention network function was examined using seed-based connectivity analyses. Results. Greater daily physical activity was associated with increased interhemispheric connectivity of the superior parietal lobule in the dorsal attention network (DAN; P <.05, false discovery rate corrected). This relationship was not explained by stroke lesion volume. Importantly, stronger connectivity in this region was related to faster reaction time in 3 attention tasks, as revealed by robust linear regression. The relationship remained after adjusting for age, gray matter volume, and white matter hyperintensity load. Conclusions. Daily physical activity was associated with increased resting interhemispheric connectivity of the DAN. Increased connectivity was associated with faster attention performance, suggesting a cognitive correlate to increased network connectivity. Attentional modulation by physical activity represents a key focus for intervention studies.

Original languageEnglish
Pages (from-to)157-167
Number of pages11
JournalNeurorehabilitation and Neural Repair
Volume31
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • attention
  • cognition
  • fMRI
  • physical activity
  • stroke

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