Phototherapy in transport for neonates with unconjugated hyperbilirubinaemia

Michelle Waterham, Risha Bhatia, Susan Donath, Charlotte Molesworth, Kenneth Tan, Michael Stewart

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aim: In Victoria, neonates with severe unconjugated hyperbilirubinaemia at risk of requiring exchange transfusion are retrieved by the Paediatric Infant Perinatal Emergency Retrieval Service and transferred to a Neonatal Intensive Care Unit where an exchange transfusion can be performed if necessary. Transfer may result in prolonged periods without phototherapy in neonates at risk of developing bilirubin encephalopathy. We aimed to describe our experience of the introduction of phototherapy using a portable phototherapy unit during transport. 

Methods: Neonates with a primary diagnosis of severe unconjugated hyperbilirubinaemia were identified from the Paediatric Infant Perinatal Emergency Retrieval clinical database over an 11-year period. Demographic and clinical data including gestation, age at transport, serum bilirubin levels pre- and post-transport, use of phototherapy during transport (PTDT), likely diagnosis, and use of exchange transfusion were included. 

Results: A total of 147 neonates were included with 104 neonates receiving PTDT and 43 who did not. Neonates who received PTDT were less likely to require exchange transfusion, 19.2% versus 34.9%, odds ratio 0.44 (95% CI 0.2-0.98), P = 0.05. However, after correction for factors appearing to be related to use of exchange transfusion, the odds ratio increased to 0.58 (95% CI 0.21-1.63), P = 0.3. There was a greater reduction in the pre- to post-transport total serum bilirubin levels (μmol/L) for the group receiving PTDT (mean 46.3, SD 64.6) versus no PTDT (mean 26.1, SD 62.5), but this did not reach significance, P = 0.08. 

Conclusions: Phototherapy during neonatal transport is feasible and safe and may result in a decreased requirement for subsequent exchange transfusion.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalJournal of Paediatrics and Child Health
Volume52
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • hyperbilirubinaemia
  • jaundice
  • phototherapy
  • retrieval
  • transport

Cite this

Waterham, Michelle ; Bhatia, Risha ; Donath, Susan ; Molesworth, Charlotte ; Tan, Kenneth ; Stewart, Michael. / Phototherapy in transport for neonates with unconjugated hyperbilirubinaemia. In: Journal of Paediatrics and Child Health. 2016 ; Vol. 52, No. 1. pp. 67-71.
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abstract = "Aim: In Victoria, neonates with severe unconjugated hyperbilirubinaemia at risk of requiring exchange transfusion are retrieved by the Paediatric Infant Perinatal Emergency Retrieval Service and transferred to a Neonatal Intensive Care Unit where an exchange transfusion can be performed if necessary. Transfer may result in prolonged periods without phototherapy in neonates at risk of developing bilirubin encephalopathy. We aimed to describe our experience of the introduction of phototherapy using a portable phototherapy unit during transport. Methods: Neonates with a primary diagnosis of severe unconjugated hyperbilirubinaemia were identified from the Paediatric Infant Perinatal Emergency Retrieval clinical database over an 11-year period. Demographic and clinical data including gestation, age at transport, serum bilirubin levels pre- and post-transport, use of phototherapy during transport (PTDT), likely diagnosis, and use of exchange transfusion were included. Results: A total of 147 neonates were included with 104 neonates receiving PTDT and 43 who did not. Neonates who received PTDT were less likely to require exchange transfusion, 19.2{\%} versus 34.9{\%}, odds ratio 0.44 (95{\%} CI 0.2-0.98), P = 0.05. However, after correction for factors appearing to be related to use of exchange transfusion, the odds ratio increased to 0.58 (95{\%} CI 0.21-1.63), P = 0.3. There was a greater reduction in the pre- to post-transport total serum bilirubin levels (μmol/L) for the group receiving PTDT (mean 46.3, SD 64.6) versus no PTDT (mean 26.1, SD 62.5), but this did not reach significance, P = 0.08. Conclusions: Phototherapy during neonatal transport is feasible and safe and may result in a decreased requirement for subsequent exchange transfusion.",
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Phototherapy in transport for neonates with unconjugated hyperbilirubinaemia. / Waterham, Michelle; Bhatia, Risha; Donath, Susan; Molesworth, Charlotte; Tan, Kenneth; Stewart, Michael.

In: Journal of Paediatrics and Child Health, Vol. 52, No. 1, 01.01.2016, p. 67-71.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Phototherapy in transport for neonates with unconjugated hyperbilirubinaemia

AU - Waterham, Michelle

AU - Bhatia, Risha

AU - Donath, Susan

AU - Molesworth, Charlotte

AU - Tan, Kenneth

AU - Stewart, Michael

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AB - Aim: In Victoria, neonates with severe unconjugated hyperbilirubinaemia at risk of requiring exchange transfusion are retrieved by the Paediatric Infant Perinatal Emergency Retrieval Service and transferred to a Neonatal Intensive Care Unit where an exchange transfusion can be performed if necessary. Transfer may result in prolonged periods without phototherapy in neonates at risk of developing bilirubin encephalopathy. We aimed to describe our experience of the introduction of phototherapy using a portable phototherapy unit during transport. Methods: Neonates with a primary diagnosis of severe unconjugated hyperbilirubinaemia were identified from the Paediatric Infant Perinatal Emergency Retrieval clinical database over an 11-year period. Demographic and clinical data including gestation, age at transport, serum bilirubin levels pre- and post-transport, use of phototherapy during transport (PTDT), likely diagnosis, and use of exchange transfusion were included. Results: A total of 147 neonates were included with 104 neonates receiving PTDT and 43 who did not. Neonates who received PTDT were less likely to require exchange transfusion, 19.2% versus 34.9%, odds ratio 0.44 (95% CI 0.2-0.98), P = 0.05. However, after correction for factors appearing to be related to use of exchange transfusion, the odds ratio increased to 0.58 (95% CI 0.21-1.63), P = 0.3. There was a greater reduction in the pre- to post-transport total serum bilirubin levels (μmol/L) for the group receiving PTDT (mean 46.3, SD 64.6) versus no PTDT (mean 26.1, SD 62.5), but this did not reach significance, P = 0.08. Conclusions: Phototherapy during neonatal transport is feasible and safe and may result in a decreased requirement for subsequent exchange transfusion.

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KW - jaundice

KW - phototherapy

KW - retrieval

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