Photoswitchable Molecules in Long-Wavelength Light-Responsive Drug Delivery: From Molecular Design to Applications

Shiyang Jia, Wye Khay Fong, Bim Graham, Ben J. Boyd

Research output: Contribution to journalReview ArticleResearchpeer-review

72 Citations (Scopus)


Stimuli-responsive nanocarriers can release their bioactive cargo "on demand", potentially improving the selectivity, specificity, and efficacy of therapeutic drugs. Light of wavelengths between 650-1100 nm is a unique stimulus with many advantages. It is noninvasive and "bio-friendly" and can be manipulated with precision and ease. Many light-responsive nanocarriers reported in the literature employ photochromic molecules that undergo reversible isomerization upon irradiation, thereby functioning as gates or switches for the release of encapsulated bioactive compounds. This review surveys the design, synthesis, function, and application of one-photon visible and near-infrared light-triggered photoswitchable compounds in the development of long-wavelength light-responsive nanocarriers.

Original languageEnglish
Pages (from-to)2873-2887
Number of pages15
JournalChemistry of Materials
Issue number9
Publication statusPublished - 8 May 2018

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