Photoswitchable Janus glycodendrimer micelles as multivalent inhibitors of LecA and LecB from Pseudomonas aeruginosa

Yingxue Hu, Ghamdan Beshr, Christopher J. Garvey, Rico F. Tabor, Alexander Titz, Brendan L. Wilkinson

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

The first example of the self-assembly and lectin binding properties of photoswitchable glycodendrimer micelles is reported. Light-addressable micelles were assembled from a library of 12 amphiphilic Janus glycodendrimers composed of variable carbohydrate head groups and hydrophobic tail groups linked to an azobenzene core. Spontaneous association in water gave cylindrical micelles with uniform size distribution as determined by dynamic light scattering (DLS) and small angle neutron scattering (SANS). Trans-cis photoisomerization of the azobenzene dendrimer core was used to probe the self-assembly behaviour and lectin binding properties of cylindrical micelles, revealing moderate-to-potent inhibition of lectins LecA and LecB from Pseudomonas aeruginosa.

Original languageEnglish
Pages (from-to)605-612
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume159
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • Janus glycodendrimer
  • Lectin inhibitors
  • Photoswitchable amphiphiles

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