Projects per year
Abstract
The first example of the self-assembly and lectin binding properties of photoswitchable glycodendrimer micelles is reported. Light-addressable micelles were assembled from a library of 12 amphiphilic Janus glycodendrimers composed of variable carbohydrate head groups and hydrophobic tail groups linked to an azobenzene core. Spontaneous association in water gave cylindrical micelles with uniform size distribution as determined by dynamic light scattering (DLS) and small angle neutron scattering (SANS). Trans-cis photoisomerization of the azobenzene dendrimer core was used to probe the self-assembly behaviour and lectin binding properties of cylindrical micelles, revealing moderate-to-potent inhibition of lectins LecA and LecB from Pseudomonas aeruginosa.
Original language | English |
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Pages (from-to) | 605-612 |
Number of pages | 8 |
Journal | Colloids and Surfaces B: Biointerfaces |
Volume | 159 |
DOIs | |
Publication status | Published - 1 Nov 2017 |
Keywords
- Janus glycodendrimer
- Lectin inhibitors
- Photoswitchable amphiphiles
Projects
- 1 Finished
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Access to biomimetic carbohydrate receptors using dynamic combinatorial chemistry
Wilkinson, B.
Australian Research Council (ARC)
15/05/13 → 28/04/16
Project: Research