Photoswitchable carbohydrate-based fluorosurfactants as tuneable ice recrystallization inhibitors

Madeleine K. Adam, Yingxue Hu, Jessica S. Poisson, Matthew J. Pottage, Robert N Ben, Brendan L. Wilkinson

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Cryopreservation is an important technique employed for the storage and preservation of biological tissues and cells. The limited effectiveness and significant toxicity of conventionally-used cryoprotectants, such as DMSO, have prompted efforts toward the rational design of less toxic alternatives, including carbohydrate-based surfactants. In this paper, we report the modular synthesis and ice recrystallization inhibition (IRI) activity of a library of variably substituted, carbohydrate-based fluorosurfactants. Carbohydrate-based fluorosurfactants possessed a variable mono- or disaccharide head group appended to a hydrophobic fluoroalkyl-substituted azobenzene tail group. Light-addressable fluorosurfactants displayed weak-to-moderate IRI activity that could be tuned through selection of carbohydrate head group, position of the trifluoroalkyl group on the azobenzene ring, and isomeric state of the azobenzene tail fragment.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCarbohydrate Research
Volume439
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • Carbohydrate-based fluorosurfactants
  • Ice recrystallization inhibitors
  • Photoswitchable fluorosurfactants

Cite this