Photon-counting, energy-resolving and super-resolution phase contrast X-ray imaging using an integrating detector.

Dylan W. O'Connell, Kaye S. Morgan, Gary Ruben, Florian Schaff, Linda C.P. Croton, Genevieve A. Buckley, David M. Paganin, Kentaro Uesugi, Marcus J. Kitchen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This work demonstrates the use of a scientific-CMOS (sCMOS) energy-integrating detector as a photon-counting detector, thereby eliminating dark current and read-out noise issues, that simultaneously provides both energy resolution and sub-pixel spatial resolution for X-ray imaging. These capabilities are obtained by analyzing visible light photon clouds that result when X-ray photons produce fluorescence from a scintillator in front of the visible light sensor. Using low-fluence monochromatic X-ray projections to avoid overlapping photon clouds, the centroid of individual X-ray photon interactions was identified. This enabled a tripling of the spatial resolution of the detector to 6.71-0.04 μm. By calculating the total charge deposited by this interaction, an energy resolution of 61.2-0.1% at 17 keV was obtained. When combined with propagation-based phase contrast imaging and phase retrieval, a signal-to-noise ratio of up to 15-3 was achieved for an X-ray fluence of less than 3 photons/mm2.

Original languageEnglish
Pages (from-to)7080-7094
Number of pages15
JournalOptics Express
Volume28
Issue number5
DOIs
Publication statusPublished - 2 Mar 2020

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