Photolabile Hydrogels Responsive to Broad Spectrum Visible Light for Selective Cell Release

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We introduce an efficient method for the preparation of photolabile polymer linkers to be used in the fabrication of bioorthogonal and photodegradable hydrogels. The versatility of this synthesis strategy allows for incorporation of a series of chromophores responsive to addressable wavelengths of UV and broad spectrum visible light. Consequently, selective release of different cell types from composite hydrogels by user-defined timing can be achieved by irradiating the materials with different wavelengths of light.

Original languageEnglish
Pages (from-to)32441-32445
Number of pages5
JournalACS Applied Materials and Interfaces
Volume9
Issue number38
DOIs
Publication statusPublished - 27 Sep 2017

Keywords

  • bioorthogonal click
  • cell release
  • hydrogel
  • photodegradation
  • visible light

Cite this

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title = "Photolabile Hydrogels Responsive to Broad Spectrum Visible Light for Selective Cell Release",
abstract = "We introduce an efficient method for the preparation of photolabile polymer linkers to be used in the fabrication of bioorthogonal and photodegradable hydrogels. The versatility of this synthesis strategy allows for incorporation of a series of chromophores responsive to addressable wavelengths of UV and broad spectrum visible light. Consequently, selective release of different cell types from composite hydrogels by user-defined timing can be achieved by irradiating the materials with different wavelengths of light.",
keywords = "bioorthogonal click, cell release, hydrogel, photodegradation, visible light",
author = "Truong, {Vinh X.} and Fanyi Li and Forsythe, {John S.}",
year = "2017",
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doi = "10.1021/acsami.7b11517",
language = "English",
volume = "9",
pages = "32441--32445",
journal = "ACS Applied Materials and Interfaces",
issn = "1944-8244",
publisher = "ACS Publications",
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Photolabile Hydrogels Responsive to Broad Spectrum Visible Light for Selective Cell Release. / Truong, Vinh X.; Li, Fanyi; Forsythe, John S.

In: ACS Applied Materials and Interfaces, Vol. 9, No. 38, 27.09.2017, p. 32441-32445.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

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AU - Truong, Vinh X.

AU - Li, Fanyi

AU - Forsythe, John S.

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N2 - We introduce an efficient method for the preparation of photolabile polymer linkers to be used in the fabrication of bioorthogonal and photodegradable hydrogels. The versatility of this synthesis strategy allows for incorporation of a series of chromophores responsive to addressable wavelengths of UV and broad spectrum visible light. Consequently, selective release of different cell types from composite hydrogels by user-defined timing can be achieved by irradiating the materials with different wavelengths of light.

AB - We introduce an efficient method for the preparation of photolabile polymer linkers to be used in the fabrication of bioorthogonal and photodegradable hydrogels. The versatility of this synthesis strategy allows for incorporation of a series of chromophores responsive to addressable wavelengths of UV and broad spectrum visible light. Consequently, selective release of different cell types from composite hydrogels by user-defined timing can be achieved by irradiating the materials with different wavelengths of light.

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KW - cell release

KW - hydrogel

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DO - 10.1021/acsami.7b11517

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JO - ACS Applied Materials and Interfaces

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