Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

Hiroyasu Tabe, Takuya Shimoi, Marion Boudes, Satoshi Abe, Fasseli Coulibaly, Susumu Kitagawa, Hajime Mori, Takafumi Ueno

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)


Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-κB) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.
Original languageEnglish
Pages (from-to)4545-4548
Number of pages4
JournalChemical Communications
Issue number24
Publication statusPublished - 1 Mar 2016

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