Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

Hiroyasu Tabe, Takuya Shimoi, Marion Boudes, Satoshi Abe, Fasseli Coulibaly, Susumu Kitagawa, Hajime Mori, Takafumi Ueno

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-κB) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.
Original languageEnglish
Pages (from-to)4545-4548
Number of pages4
JournalChemical Communications
Volume52
Issue number24
DOIs
Publication statusPublished - 1 Mar 2016

Cite this

Tabe, Hiroyasu ; Shimoi, Takuya ; Boudes, Marion ; Abe, Satoshi ; Coulibaly, Fasseli ; Kitagawa, Susumu ; Mori, Hajime ; Ueno, Takafumi. / Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation. In: Chemical Communications. 2016 ; Vol. 52, No. 24. pp. 4545-4548.
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abstract = "Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-κB) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.",
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Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation. / Tabe, Hiroyasu; Shimoi, Takuya; Boudes, Marion; Abe, Satoshi; Coulibaly, Fasseli; Kitagawa, Susumu; Mori, Hajime; Ueno, Takafumi.

In: Chemical Communications, Vol. 52, No. 24, 01.03.2016, p. 4545-4548.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

AU - Tabe, Hiroyasu

AU - Shimoi, Takuya

AU - Boudes, Marion

AU - Abe, Satoshi

AU - Coulibaly, Fasseli

AU - Kitagawa, Susumu

AU - Mori, Hajime

AU - Ueno, Takafumi

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AB - Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-κB) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.

UR - http://www.ncbi.nlm.nih.gov/pubmed/26940021

U2 - 10.1039/c5cc10440h

DO - 10.1039/c5cc10440h

M3 - Article

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EP - 4548

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 24

ER -