Photo and thermo dual-responsive copolymer surfaces for efficient cell capture and release

Yuwei Hao; Hongliang Liu; Guannan Li; Haijun Cui; Lei Jiang; Shutao Wang

doi:10.1002/cphc.201701145

Photo and thermo dual-responsive copolymer surfaces for efficient cell capture and release

Yuwei Hao, Hongliang Liu, Guannan Li, Haijun Cui, Lei Jiang, Shutao Wang

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface – poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays – by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing the efficiencies of cancer-cell capture and release. These enhanced efficiencies probably originate from the binary cooperative effect of two responsive building units: NiPAAm units can decrease the steric hindrance between SP units during the isomerization while SP units can facilitate phase transition of NiPAAm units. This study provides a new strategy for designing smart materials and surfaces with efficient responsiveness for biomedical applications.

Original language	English
Pages (from-to)	2107-2112
Number of pages	6
Journal	ChemPhysChem
Volume	19
Issue number	16
DOIs	https://doi.org/10.1002/cphc.201701145
Publication status	Published - 17 Aug 2018
Externally published	Yes

Keywords

cell capture and release
smart surface
stimuli-responsive material
surface chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cphc.201701145

Cite this

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title = "Photo and thermo dual-responsive copolymer surfaces for efficient cell capture and release",

abstract = "To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface – poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays – by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing the efficiencies of cancer-cell capture and release. These enhanced efficiencies probably originate from the binary cooperative effect of two responsive building units: NiPAAm units can decrease the steric hindrance between SP units during the isomerization while SP units can facilitate phase transition of NiPAAm units. This study provides a new strategy for designing smart materials and surfaces with efficient responsiveness for biomedical applications.",

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T1 - Photo and thermo dual-responsive copolymer surfaces for efficient cell capture and release

AU - Hao, Yuwei

AU - Liu, Hongliang

AU - Li, Guannan

AU - Cui, Haijun

AU - Jiang, Lei

AU - Wang, Shutao

PY - 2018/8/17

Y1 - 2018/8/17

N2 - To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface – poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays – by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing the efficiencies of cancer-cell capture and release. These enhanced efficiencies probably originate from the binary cooperative effect of two responsive building units: NiPAAm units can decrease the steric hindrance between SP units during the isomerization while SP units can facilitate phase transition of NiPAAm units. This study provides a new strategy for designing smart materials and surfaces with efficient responsiveness for biomedical applications.

AB - To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface – poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays – by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing the efficiencies of cancer-cell capture and release. These enhanced efficiencies probably originate from the binary cooperative effect of two responsive building units: NiPAAm units can decrease the steric hindrance between SP units during the isomerization while SP units can facilitate phase transition of NiPAAm units. This study provides a new strategy for designing smart materials and surfaces with efficient responsiveness for biomedical applications.

KW - cell capture and release

KW - smart surface

KW - stimuli-responsive material

KW - surface chemistry

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DO - 10.1002/cphc.201701145

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Photo and thermo dual-responsive copolymer surfaces for efficient cell capture and release

Abstract

Keywords

UN SDGs

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