Photo and thermo dual-responsive copolymer surfaces for efficient cell capture and release

Yuwei Hao, Hongliang Liu, Guannan Li, Haijun Cui, Lei Jiang, Shutao Wang

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)


To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface – poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays – by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing the efficiencies of cancer-cell capture and release. These enhanced efficiencies probably originate from the binary cooperative effect of two responsive building units: NiPAAm units can decrease the steric hindrance between SP units during the isomerization while SP units can facilitate phase transition of NiPAAm units. This study provides a new strategy for designing smart materials and surfaces with efficient responsiveness for biomedical applications.

Original languageEnglish
Pages (from-to)2107-2112
Number of pages6
Issue number16
Publication statusPublished - 17 Aug 2018
Externally publishedYes


  • cell capture and release
  • smart surface
  • stimuli-responsive material
  • surface chemistry

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