Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

Edward Robert Smith; Martin L Ford; Lawrie A Tomlinson; Chakravarthi Rajkumar; Lawrence McMahon; Stephen G Holt

doi:10.1093/ndt/gfr609

Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

Edward Robert Smith, Martin L Ford, Lawrie A Tomlinson, Chakravarthi Rajkumar, Lawrence McMahon, Stephen G Holt

Eastern Health Clinical School

Research output: Contribution to journal › Article › Research › peer-review

116 Citations (Scopus)

Abstract

We measured fetuin-A CPP levels, serum inflammatory markers [C-reactive protein (CRP), interleukin-6, tumour necrosis factor-a], oxidized low-density lipoprotein (oxLDL), bone morphogenetic protein-2 (BMP-2) and -7 (BMP-7) and aortic pulse wave velocity (APWV) in a cohort of 200 CKD patients. Serum measurements were also made in 78 healthy controls. CPP fetuin-A phosphorylation was characterized by phosphate-affinity gel chromatography

Original language	English
Pages (from-to)	1957 - 1966
Number of pages	10
Journal	Nephrology Dialysis Transplantation
Volume	27
Issue number	5
DOIs	https://doi.org/10.1093/ndt/gfr609
Publication status	Published - 2012

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title = "Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD",

abstract = "We measured fetuin-A CPP levels, serum inflammatory markers [C-reactive protein (CRP), interleukin-6, tumour necrosis factor-a], oxidized low-density lipoprotein (oxLDL), bone morphogenetic protein-2 (BMP-2) and -7 (BMP-7) and aortic pulse wave velocity (APWV) in a cohort of 200 CKD patients. Serum measurements were also made in 78 healthy controls. CPP fetuin-A phosphorylation was characterized by phosphate-affinity gel chromatography",

author = "Smith, {Edward Robert} and Ford, {Martin L} and Tomlinson, {Lawrie A} and Chakravarthi Rajkumar and Lawrence McMahon and Holt, {Stephen G}",

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Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD. / Smith, Edward Robert; Ford, Martin L; Tomlinson, Lawrie A; Rajkumar, Chakravarthi; McMahon, Lawrence; Holt, Stephen G.

In: Nephrology Dialysis Transplantation, Vol. 27, No. 5, 2012, p. 1957 - 1966.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

AU - Smith, Edward Robert

AU - Ford, Martin L

AU - Tomlinson, Lawrie A

AU - Rajkumar, Chakravarthi

AU - McMahon, Lawrence

AU - Holt, Stephen G

PY - 2012

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AB - We measured fetuin-A CPP levels, serum inflammatory markers [C-reactive protein (CRP), interleukin-6, tumour necrosis factor-a], oxidized low-density lipoprotein (oxLDL), bone morphogenetic protein-2 (BMP-2) and -7 (BMP-7) and aortic pulse wave velocity (APWV) in a cohort of 200 CKD patients. Serum measurements were also made in 78 healthy controls. CPP fetuin-A phosphorylation was characterized by phosphate-affinity gel chromatography

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U2 - 10.1093/ndt/gfr609

DO - 10.1093/ndt/gfr609

M3 - Article

VL - 27

SP - 1957

EP - 1966

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 5

ER -

Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

Abstract

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