Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

Edward Robert Smith; Martin L Ford; Lawrie A Tomlinson; Chakravarthi Rajkumar; Lawrence McMahon; Stephen G Holt

doi:10.1093/ndt/gfr609

Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

Edward Robert Smith, Martin L Ford, Lawrie A Tomlinson, Chakravarthi Rajkumar, Lawrence McMahon, Stephen G Holt

Eastern Health Clinical School

Research output: Contribution to journal › Article › Research › peer-review

98 Citations (Scopus)

Abstract

We measured fetuin-A CPP levels, serum inflammatory markers [C-reactive protein (CRP), interleukin-6, tumour necrosis factor-a], oxidized low-density lipoprotein (oxLDL), bone morphogenetic protein-2 (BMP-2) and -7 (BMP-7) and aortic pulse wave velocity (APWV) in a cohort of 200 CKD patients. Serum measurements were also made in 78 healthy controls. CPP fetuin-A phosphorylation was characterized by phosphate-affinity gel chromatography

Original language	English
Pages (from-to)	1957 - 1966
Number of pages	10
Journal	Nephrology Dialysis Transplantation
Volume	27
Issue number	5
DOIs	https://doi.org/10.1093/ndt/gfr609
Publication status	Published - 2012

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Smith, E. R., Ford, M. L., Tomlinson, L. A., Rajkumar, C., McMahon, L., & Holt, S. G. (2012). Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD. Nephrology Dialysis Transplantation, 27(5), 1957 - 1966. https://doi.org/10.1093/ndt/gfr609

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abstract = "We measured fetuin-A CPP levels, serum inflammatory markers [C-reactive protein (CRP), interleukin-6, tumour necrosis factor-a], oxidized low-density lipoprotein (oxLDL), bone morphogenetic protein-2 (BMP-2) and -7 (BMP-7) and aortic pulse wave velocity (APWV) in a cohort of 200 CKD patients. Serum measurements were also made in 78 healthy controls. CPP fetuin-A phosphorylation was characterized by phosphate-affinity gel chromatography",

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Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD. / Smith, Edward Robert; Ford, Martin L; Tomlinson, Lawrie A; Rajkumar, Chakravarthi; McMahon, Lawrence; Holt, Stephen G.

In: Nephrology Dialysis Transplantation, Vol. 27, No. 5, 2012, p. 1957 - 1966.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Holt, Stephen G

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