Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD

Edward Robert Smith, Martin L Ford, Lawrie A Tomlinson, Chakravarthi Rajkumar, Lawrence McMahon, Stephen G Holt

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Abstract

We measured fetuin-A CPP levels, serum inflammatory markers [C-reactive protein (CRP), interleukin-6, tumour necrosis factor-a], oxidized low-density lipoprotein (oxLDL), bone morphogenetic protein-2 (BMP-2) and -7 (BMP-7) and aortic pulse wave velocity (APWV) in a cohort of 200 CKD patients. Serum measurements were also made in 78 healthy controls. CPP fetuin-A phosphorylation was characterized by phosphate-affinity gel chromatography
Original languageEnglish
Pages (from-to)1957 - 1966
Number of pages10
JournalNephrology Dialysis Transplantation
Volume27
Issue number5
DOIs
Publication statusPublished - 2012

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