Phosphodiester cleavage properties of copper(II) complexes of 1,4,7-triazacyclononane ligands bearing single alkyl guanidine pendants

Linda Tjioe, Tanmaya Joshi, Craig Macdonald Forsyth, Boujemaa Moubaraki, Keith Spencer Murray, Joel Brugger, Bimbil Graham, Leone Spiccia

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Three new metal-coordinating ligands, L(1)center dot 4HCl [1-(2-guanidinoethyl)-1,4,7-triazacyclononane tetrahydrochloride], L(2)center dot 4HCl [1-(3-guanidinopropyl)-1,4,7-triazacyclononane tetrahydrochloride], and L(3)center dot 4HCl [1-(4-guanidinobutyl)-1,4,7-triazacyclononane tetrahydrochloride], have been prepared via the selective N-functionalization of 1,4,7-triazacyclononane (tacn) with ethylguanidine, propylguanidine, and butylguanidine pendants, respectively. Reaction of L(1)center dot 4HCl with Cu(ClO(4))(2)center dot 6H(2)O in basic aqueous solution led to the crystallization of a monohydroxo-bridged binuclear copper(II) complex, [Cu(2)L(2)(1)(mu-OH)](ClO(4))(3)center dot H(2)O (Cl), while for L2 and L3, mononuclear complexes of composition [Cu(L(2)H)Cl(2)]Cl center dot(MeOH)(0.5)(H(2)O)(0.5) (C2) and [Cu(L(3)H)Cl(2)]Cl center dot(DMF)(0.5)center dot(H(2)O)(0.5) (C3) were crystallized from methanol and DMF solutions, respectively.
Original languageEnglish
Pages (from-to)939 - 953
Number of pages15
JournalInorganic Chemistry
Issue number2
Publication statusPublished - 2012

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