Phosphate removal in haemodialysis: Effect of two different dialysis membranes

Miwako Mitsuhashi, Peter G. Kerr

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Phosphate removal with two different dialysis membranes (a standard cellulose acetate membrane and a high performance cellulose diacetate membrane) were studied in ten haemodialysis patients. All patients were dialysed sequentially with two membranes (surface area was 1.5 m2) against bicarbonate buffered dialysis for 4 hours three times a week. With the diacetate membrane, the instantaneous clearances of urea and phosphate after 1 hour of haemodialysis were significantly higher than with the cellulose membrane. Also, the weekly total amount of urea and phosphate removal were significantly increased with the diacetate membrane (a 15% increase in urea and a 16% increase of phosphate). Although there was a significant increase in urea reduction ratio and significantly lower post dialytic plasma urea concentration with the diacetate membrane, these for phosphate did not reach statistical significance. These data suggest that the use of the diacetate membrane potentially offer clinical benefit. However, whether 16% of phosphate removal could improve clinical control of serum phosphate levels will need further investigation.

Original languageEnglish
Pages (from-to)405-407
Number of pages3
JournalNephrology
Volume2
Issue number6
DOIs
Publication statusPublished - 1 Jan 1996

Keywords

  • Dialysis membrane
  • Haemodialysis
  • Phosphate

Cite this

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Phosphate removal in haemodialysis : Effect of two different dialysis membranes. / Mitsuhashi, Miwako; Kerr, Peter G.

In: Nephrology, Vol. 2, No. 6, 01.01.1996, p. 405-407.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Phosphate removal in haemodialysis

T2 - Effect of two different dialysis membranes

AU - Mitsuhashi, Miwako

AU - Kerr, Peter G.

PY - 1996/1/1

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AB - Phosphate removal with two different dialysis membranes (a standard cellulose acetate membrane and a high performance cellulose diacetate membrane) were studied in ten haemodialysis patients. All patients were dialysed sequentially with two membranes (surface area was 1.5 m2) against bicarbonate buffered dialysis for 4 hours three times a week. With the diacetate membrane, the instantaneous clearances of urea and phosphate after 1 hour of haemodialysis were significantly higher than with the cellulose membrane. Also, the weekly total amount of urea and phosphate removal were significantly increased with the diacetate membrane (a 15% increase in urea and a 16% increase of phosphate). Although there was a significant increase in urea reduction ratio and significantly lower post dialytic plasma urea concentration with the diacetate membrane, these for phosphate did not reach statistical significance. These data suggest that the use of the diacetate membrane potentially offer clinical benefit. However, whether 16% of phosphate removal could improve clinical control of serum phosphate levels will need further investigation.

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