Phenotypic assessment of male fertility status in transgenic animal models

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Abstract

This chapter describes the approach to de fi ne the cause of male infertility in a genetically modi fi ed male mouse. It provides a guide to the establishment of the infertility status and whether it is due to the failure of mating or due to abnormalities of the sperm output, motility, and morphology. Further assessments de fi ne the nature of the spermatogenic defects and their severity and are designed to determine the pathogenic mechanisms involved. 

Original languageEnglish
Pages (from-to)531-548
Number of pages18
JournalMethods in Molecular Biology
Volume927
DOIs
Publication statusPublished - 2013

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