TY - JOUR
T1 - Phenotypic assessment of male fertility status in transgenic animal models
AU - de Kretser, David Morritz
AU - O'Donnell, Liza
PY - 2013
Y1 - 2013
N2 - This chapter describes the approach to de fi ne the cause of male infertility in a genetically modi fi ed male mouse. It provides a guide to the establishment of the infertility status and whether it is due to the failure of mating or due to abnormalities of the sperm output, motility, and morphology. Further assessments de fi ne the nature of the spermatogenic defects and their severity and are designed to determine the pathogenic mechanisms involved.
AB - This chapter describes the approach to de fi ne the cause of male infertility in a genetically modi fi ed male mouse. It provides a guide to the establishment of the infertility status and whether it is due to the failure of mating or due to abnormalities of the sperm output, motility, and morphology. Further assessments de fi ne the nature of the spermatogenic defects and their severity and are designed to determine the pathogenic mechanisms involved.
UR - http://www.scopus.com/inward/record.url?scp=84934435671&partnerID=8YFLogxK
U2 - 10.1007/978-1-62703-38-0_45
DO - 10.1007/978-1-62703-38-0_45
M3 - Article
VL - 927
SP - 531
EP - 548
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
SN - 1064-3745
ER -