Phenotypic assessment of male fertility status in transgenic animal models

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Abstract

This chapter describes the approach to de fi ne the cause of male infertility in a genetically modi fi ed male mouse. It provides a guide to the establishment of the infertility status and whether it is due to the failure of mating or due to abnormalities of the sperm output, motility, and morphology. Further assessments de fi ne the nature of the spermatogenic defects and their severity and are designed to determine the pathogenic mechanisms involved. 

Original languageEnglish
Title of host publicationSpermatogenesis
Subtitle of host publicationMethods and Protocols
EditorsDouglas T. Carrell, Kenneth I. Aston
Place of PublicationTotowa, NJ USA
PublisherHumana Press
Chapter45
Pages531-548
Number of pages18
Edition1st
ISBN (Print)9781627030373
DOIs
Publication statusPublished - 2013

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
Volume927
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

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