Phasic respiratory activity in the fetal lamb during late gestation and labour

P. J. Berger, A. M. Walker, R. Horne, V. Brodecky, M. H. Wilkinson, F. Wilson, J. E. Maloney

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Abstract

We quantified the respiratory activity of 9 fetal lambs using computer-analysis of the diaphragmatic electromyogram (EMG) obtained during 2 h recording sessions interspersed over the last 13 days of gestation. The fetuses delivered unassisted at an average gestational age of 145 days (term = 147 days). During the last 2 h of labour the number of phasic EMG bursts (breaths) averaged 3% of the peak recorded earlier in the study. This decline in breathing began at least 2 days before labour and resulted predominantly from the fetus spending an increasing proportion of time in apnoea. Respiratory rate within epochs of breathing also fell significantly 1 day before labour, and the proportion of time spent in the low voltage electrocortical state declined once labour commenced. No significant change occurred in arterial PO2, PCO2 or pH over the study period. We conclude that fetal respiratory activity falls well before the onset of labour, largely as a result of increased apnoea, and that the decline does not result from the development of a progressive hypoxaemia associated with labour.

Original languageEnglish
Pages (from-to)55-68
Number of pages14
JournalRespiration Physiology
Volume65
Issue number1
DOIs
Publication statusPublished - 1 Jan 1986

Keywords

  • Arterial blood
  • Breathing pattern
  • Diaphragm
  • Fetus
  • Gestation
  • Labour
  • Lamb
  • Newborn mammal

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