Phase-contrast clinical breast CT: Optimization of imaging setups and reconstruction workflows

Giuliana Tromba; Serena Pacilè; Yakov I. Nesterets; Francesco Brun; Christian Dullin; Diego Dreossi; Sheridan C. Mayo; Andrew W. Stevenson; Konstantin M Pavlov; Markus J Kitchen; Darren Thompson; Jeremy M C Brown; Darren Lockie; Maura Tonutti; Fulvio Stacul; Fabrizio Zanconati; Agostino Accardo; Timur E Gureyev

doi:10.1007/978-3-319-41546-8_78

Phase-contrast clinical breast CT: Optimization of imaging setups and reconstruction workflows

Giuliana Tromba, Serena Pacilè, Yakov I. Nesterets, Francesco Brun, Christian Dullin, Diego Dreossi, Sheridan C. Mayo, Andrew W. Stevenson, Konstantin M Pavlov, Markus J Kitchen, Darren Thompson, Jeremy M C Brown, Darren Lockie, Maura Tonutti, Fulvio Stacul, Fabrizio Zanconati, Agostino Accardo, Timur E Gureyev

School of Physics and Astronomy

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

3 Citations (Scopus)

Abstract

We present the outcomes of combined feasibility studies carried out at Elettra and Australian Synchrotron to evaluate novel protocols for three dimensional (3D) mammographic phase contrast imaging. A custom designed plastic phantom and some tissue samples have been studied at diverse resolution scales and experimental conditions. Several computed tomography (CT) reconstruction algorithms with different pre-processing and post-processing steps have been considered. Special attention was paid to the effect of phase retrieval on the diagnostic value of the reconstructed images. The images were quantitatively evaluated using objective quality indices in comparison with subjective assessments performed by three experienced radiologists and one pathologist. We show that the propagation-based phase-contrast imaging (PBI) leads to substantial improvement to the contrast-to-noise and to the intrinsic quality of the reconstructed CT images compared with conventional techniques as well as to an important reduction of the delivered doses, thus opening the way to clinical implementations.

Original language	English
Title of host publication	Breast Imaging - 13th International Workshop, IWDM 2016, Proceedings
Editors	Anders Tingberg, Kristina Lång, Pontus Timberg
Publisher	Springer-Verlag London Ltd.
Pages	625-634
Number of pages	10
Volume	9699
ISBN (Print)	9783319415451
DOIs	https://doi.org/10.1007/978-3-319-41546-8_78
Publication status	Published - 2016
Event	International Workshop on Digital Mammography 2016 - Malmo, Sweden Duration: 19 Jun 2016 → 22 Jun 2016 Conference number: 13th http://www.springer.com/gp/book/9783319415451

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	9699
ISSN (Print)	03029743
ISSN (Electronic)	16113349

Workshop

Workshop	International Workshop on Digital Mammography 2016
Abbreviated title	IWDM 2016
Country	Sweden
City	Malmo
Period	19/06/16 → 22/06/16
Other	WDM: International Workshop on Digital Mammography Proceedings published in a Spriner book Breast Imaging 13th International Workshop, IWDM 2016, Malmö, Sweden, June 19-22, 2016, Proceedings Editors: Tingberg, Anders, Lång, Kristina, Timberg, Pontus (Eds.)
Internet address	http://www.springer.com/gp/book/9783319415451

Keywords

Breast CT
Computed tomography
Mammography
Phase contrast
Synchrotron radiation
X-rays

Access to Document

10.1007/978-3-319-41546-8_78

Link to publication in Scopus

Cite this

Tromba, G., Pacilè, S., Nesterets, Y. I., Brun, F., Dullin, C., Dreossi, D., Mayo, S. C., Stevenson, A. W., Pavlov, K. M., Kitchen, M. J., Thompson, D., Brown, J. M. C., Lockie, D., Tonutti, M., Stacul, F., Zanconati, F., Accardo, A., & Gureyev, T. E. (2016). Phase-contrast clinical breast CT: Optimization of imaging setups and reconstruction workflows. In A. Tingberg, K. Lång, & P. Timberg (Eds.), Breast Imaging - 13th International Workshop, IWDM 2016, Proceedings (Vol. 9699, pp. 625-634). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9699). Springer-Verlag London Ltd.. https://doi.org/10.1007/978-3-319-41546-8_78

Tromba, Giuliana ; Pacilè, Serena ; Nesterets, Yakov I. ; Brun, Francesco ; Dullin, Christian ; Dreossi, Diego ; Mayo, Sheridan C. ; Stevenson, Andrew W. ; Pavlov, Konstantin M ; Kitchen, Markus J ; Thompson, Darren ; Brown, Jeremy M C ; Lockie, Darren ; Tonutti, Maura ; Stacul, Fulvio ; Zanconati, Fabrizio ; Accardo, Agostino ; Gureyev, Timur E. / Phase-contrast clinical breast CT : Optimization of imaging setups and reconstruction workflows. Breast Imaging - 13th International Workshop, IWDM 2016, Proceedings. editor / Anders Tingberg ; Kristina Lång ; Pontus Timberg. Vol. 9699 Springer-Verlag London Ltd., 2016. pp. 625-634 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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abstract = "We present the outcomes of combined feasibility studies carried out at Elettra and Australian Synchrotron to evaluate novel protocols for three dimensional (3D) mammographic phase contrast imaging. A custom designed plastic phantom and some tissue samples have been studied at diverse resolution scales and experimental conditions. Several computed tomography (CT) reconstruction algorithms with different pre-processing and post-processing steps have been considered. Special attention was paid to the effect of phase retrieval on the diagnostic value of the reconstructed images. The images were quantitatively evaluated using objective quality indices in comparison with subjective assessments performed by three experienced radiologists and one pathologist. We show that the propagation-based phase-contrast imaging (PBI) leads to substantial improvement to the contrast-to-noise and to the intrinsic quality of the reconstructed CT images compared with conventional techniques as well as to an important reduction of the delivered doses, thus opening the way to clinical implementations.",

keywords = "Breast CT, Computed tomography, Mammography, Phase contrast, Synchrotron radiation, X-rays",

author = "Giuliana Tromba and Serena Pacil{\`e} and Nesterets, {Yakov I.} and Francesco Brun and Christian Dullin and Diego Dreossi and Mayo, {Sheridan C.} and Stevenson, {Andrew W.} and Pavlov, {Konstantin M} and Kitchen, {Markus J} and Darren Thompson and Brown, {Jeremy M C} and Darren Lockie and Maura Tonutti and Fulvio Stacul and Fabrizio Zanconati and Agostino Accardo and Gureyev, {Timur E}",

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Tromba, G, Pacilè, S, Nesterets, YI, Brun, F, Dullin, C, Dreossi, D, Mayo, SC, Stevenson, AW, Pavlov, KM, Kitchen, MJ, Thompson, D, Brown, JMC, Lockie, D, Tonutti, M, Stacul, F, Zanconati, F, Accardo, A & Gureyev, TE 2016, Phase-contrast clinical breast CT: Optimization of imaging setups and reconstruction workflows. in A Tingberg, K Lång & P Timberg (eds), Breast Imaging - 13th International Workshop, IWDM 2016, Proceedings. vol. 9699, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 9699, Springer-Verlag London Ltd., pp. 625-634, International Workshop on Digital Mammography 2016, Malmo, Sweden, 19/06/16. https://doi.org/10.1007/978-3-319-41546-8_78

Phase-contrast clinical breast CT : Optimization of imaging setups and reconstruction workflows. / Tromba, Giuliana; Pacilè, Serena; Nesterets, Yakov I.; Brun, Francesco; Dullin, Christian; Dreossi, Diego; Mayo, Sheridan C.; Stevenson, Andrew W.; Pavlov, Konstantin M; Kitchen, Markus J; Thompson, Darren; Brown, Jeremy M C; Lockie, Darren; Tonutti, Maura; Stacul, Fulvio; Zanconati, Fabrizio; Accardo, Agostino; Gureyev, Timur E.

Breast Imaging - 13th International Workshop, IWDM 2016, Proceedings. ed. / Anders Tingberg; Kristina Lång; Pontus Timberg. Vol. 9699 Springer-Verlag London Ltd., 2016. p. 625-634 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9699).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AB - We present the outcomes of combined feasibility studies carried out at Elettra and Australian Synchrotron to evaluate novel protocols for three dimensional (3D) mammographic phase contrast imaging. A custom designed plastic phantom and some tissue samples have been studied at diverse resolution scales and experimental conditions. Several computed tomography (CT) reconstruction algorithms with different pre-processing and post-processing steps have been considered. Special attention was paid to the effect of phase retrieval on the diagnostic value of the reconstructed images. The images were quantitatively evaluated using objective quality indices in comparison with subjective assessments performed by three experienced radiologists and one pathologist. We show that the propagation-based phase-contrast imaging (PBI) leads to substantial improvement to the contrast-to-noise and to the intrinsic quality of the reconstructed CT images compared with conventional techniques as well as to an important reduction of the delivered doses, thus opening the way to clinical implementations.

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Tromba G, Pacilè S, Nesterets YI, Brun F, Dullin C, Dreossi D et al. Phase-contrast clinical breast CT: Optimization of imaging setups and reconstruction workflows. In Tingberg A, Lång K, Timberg P, editors, Breast Imaging - 13th International Workshop, IWDM 2016, Proceedings. Vol. 9699. Springer-Verlag London Ltd. 2016. p. 625-634. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-319-41546-8_78