Phase-contrast clinical breast CT: Optimization of imaging setups and reconstruction workflows

Giuliana Tromba, Serena Pacilè, Yakov I. Nesterets, Francesco Brun, Christian Dullin, Diego Dreossi, Sheridan C. Mayo, Andrew W. Stevenson, Konstantin M Pavlov, Markus J Kitchen, Darren Thompson, Jeremy M C Brown, Darren Lockie, Maura Tonutti, Fulvio Stacul, Fabrizio Zanconati, Agostino Accardo, Timur E Gureyev

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

3 Citations (Scopus)


We present the outcomes of combined feasibility studies carried out at Elettra and Australian Synchrotron to evaluate novel protocols for three dimensional (3D) mammographic phase contrast imaging. A custom designed plastic phantom and some tissue samples have been studied at diverse resolution scales and experimental conditions. Several computed tomography (CT) reconstruction algorithms with different pre-processing and post-processing steps have been considered. Special attention was paid to the effect of phase retrieval on the diagnostic value of the reconstructed images. The images were quantitatively evaluated using objective quality indices in comparison with subjective assessments performed by three experienced radiologists and one pathologist. We show that the propagation-based phase-contrast imaging (PBI) leads to substantial improvement to the contrast-to-noise and to the intrinsic quality of the reconstructed CT images compared with conventional techniques as well as to an important reduction of the delivered doses, thus opening the way to clinical implementations.

Original languageEnglish
Title of host publicationBreast Imaging - 13th International Workshop, IWDM 2016, Proceedings
EditorsAnders Tingberg, Kristina Lång, Pontus Timberg
PublisherSpringer-Verlag London Ltd.
Number of pages10
ISBN (Print)9783319415451
Publication statusPublished - 2016
EventInternational Workshop on Digital Mammography 2016 - Malmo, Sweden
Duration: 19 Jun 201622 Jun 2016
Conference number: 13th

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
ISSN (Print)03029743
ISSN (Electronic)16113349


WorkshopInternational Workshop on Digital Mammography 2016
Abbreviated titleIWDM 2016
OtherWDM: International Workshop on Digital Mammography

Proceedings published in a Spriner book
Breast Imaging
13th International Workshop, IWDM 2016, Malmö, Sweden, June 19-22, 2016, Proceedings
Editors: Tingberg, Anders, Lång, Kristina, Timberg, Pontus (Eds.)
Internet address


  • Breast CT
  • Computed tomography
  • Mammography
  • Phase contrast
  • Synchrotron radiation
  • X-rays

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