Phase and antigenic variation - the impact on strategies for bacterial vaccine design

Duncan Maskell, Gad Frankel, Gordon Dougan

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Many pathogens have the ability to vary the antigenic composition of surface-associated antigens. Often, this variation is mediated by the regulation of gene expression. By varying its antigenicity, the pathogen is able to avoid host immune responses more efficiently; however, this makes the design of vaccines against pathogens that exhibit antigenic variation difficult. In this review, we use the pathogenic Neisseria as an example of antigenically variable bacteria and discuss some attempts to overcome the problems of vaccine design posed by such organisms.

Original languageEnglish
Pages (from-to)506-510
Number of pages5
JournalTrends in Biotechnology
Volume11
Issue number12
DOIs
Publication statusPublished - 1 Jan 1993
Externally publishedYes

Cite this

@article{de59e64ef82948d7ac4c51a293b44a6a,
title = "Phase and antigenic variation - the impact on strategies for bacterial vaccine design",
abstract = "Many pathogens have the ability to vary the antigenic composition of surface-associated antigens. Often, this variation is mediated by the regulation of gene expression. By varying its antigenicity, the pathogen is able to avoid host immune responses more efficiently; however, this makes the design of vaccines against pathogens that exhibit antigenic variation difficult. In this review, we use the pathogenic Neisseria as an example of antigenically variable bacteria and discuss some attempts to overcome the problems of vaccine design posed by such organisms.",
author = "Duncan Maskell and Gad Frankel and Gordon Dougan",
year = "1993",
month = "1",
day = "1",
doi = "10.1016/0167-7799(93)90029-9",
language = "English",
volume = "11",
pages = "506--510",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier",
number = "12",

}

Phase and antigenic variation - the impact on strategies for bacterial vaccine design. / Maskell, Duncan; Frankel, Gad; Dougan, Gordon.

In: Trends in Biotechnology, Vol. 11, No. 12, 01.01.1993, p. 506-510.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Phase and antigenic variation - the impact on strategies for bacterial vaccine design

AU - Maskell, Duncan

AU - Frankel, Gad

AU - Dougan, Gordon

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Many pathogens have the ability to vary the antigenic composition of surface-associated antigens. Often, this variation is mediated by the regulation of gene expression. By varying its antigenicity, the pathogen is able to avoid host immune responses more efficiently; however, this makes the design of vaccines against pathogens that exhibit antigenic variation difficult. In this review, we use the pathogenic Neisseria as an example of antigenically variable bacteria and discuss some attempts to overcome the problems of vaccine design posed by such organisms.

AB - Many pathogens have the ability to vary the antigenic composition of surface-associated antigens. Often, this variation is mediated by the regulation of gene expression. By varying its antigenicity, the pathogen is able to avoid host immune responses more efficiently; however, this makes the design of vaccines against pathogens that exhibit antigenic variation difficult. In this review, we use the pathogenic Neisseria as an example of antigenically variable bacteria and discuss some attempts to overcome the problems of vaccine design posed by such organisms.

UR - http://www.scopus.com/inward/record.url?scp=0027897652&partnerID=8YFLogxK

U2 - 10.1016/0167-7799(93)90029-9

DO - 10.1016/0167-7799(93)90029-9

M3 - Review Article

VL - 11

SP - 506

EP - 510

JO - Trends in Biotechnology

JF - Trends in Biotechnology

SN - 0167-7799

IS - 12

ER -