Background: The pharmacists?roles have been expanding around the globe in the recent years. In Malaysia, healthcare system is a two-tier system consisting of the public and private sectors. Pharmacy service in Malaysia came into existence in 1951 with the enactment of three main legislations governing its profession, namely, the Registration of Pharmacist Act 1951, Poison Act 1952 and Dangerous Drug Act 1952. However, the absence of dispensing right has limited the community pharmacists? professional roles to deliver pharmaceutical care, optimise their clinical knowledge and utilise their skill. Aims: To describe the overview of pharmacy practice in Malaysia, by discussing on the history, challenges and future of this profession.