Pharmacoresistance – Epidemiology, mechanisms, and impact on epilepsy treatment

Mubeen Janmohamed, Martin J. Brodie, Patrick Kwan

Research output: Contribution to journalReview ArticleResearchpeer-review

80 Citations (Scopus)


Understanding the natural history of and factors associated with pharmacoresistant epilepsy provides the foundation for formulating mechanistic hypotheses that can be evaluated to drive the development of novel treatments. This article reviews the modern definition of drug-resistant epilepsy, its prevalence and incidence, risk factors, hypothesized mechanisms, and the implication of recognizing pharmacoresistance in therapeutic strategies. This article is part of the special issue entitled ‘New Epilepsy Therapies for the 21st Century – From Antiseizure Drugs to Prevention, Modification and Cure of Epilepsy’.

Original languageEnglish
Article number107790
Number of pages9
Publication statusPublished - 15 May 2020


  • Epidemiology
  • Epilepsy
  • Mechanisms
  • Pharmacoresistance
  • Risk factors
  • Treatment

Cite this